Topical Application of OJI-204 Alleviates Skin Dryness, Dry Skin-Induced Itch, and Mechanical Alloknesis
Abstract
1. Introduction
2. Materials and Methods
2.1. Animals
2.2. Treatment for Cutaneous Barrier Disruption
2.3. Evaluation of Skin Condition and Dermatitis
2.4. Evaluation of OJI-204 for Scratching Behavior and Sedative Effects
2.5. M-Alloknesis Assay
2.6. Statistical Analyses
3. Results
3.1. Effects of OJI-204 on Dry Skin Scores, TEWL, and SC Hydration
3.2. Effects of the Topical Application of OJI-204 on Spontaneous Itch and m-Alloknesis
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
AEW | Acetone, diethyl ether, and water |
HR | Heparinoid |
M-alloknesis | Mechanical alloknesis |
PPS | Pentosan polysulfate sodium |
SC | Stratum corneum |
TEWL | Transepidermal water loss |
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Toyama, S.; Nakamura, T.; Tominaga, M.; Takamori, K. Topical Application of OJI-204 Alleviates Skin Dryness, Dry Skin-Induced Itch, and Mechanical Alloknesis. Biomedicines 2025, 13, 556. https://doi.org/10.3390/biomedicines13030556
Toyama S, Nakamura T, Tominaga M, Takamori K. Topical Application of OJI-204 Alleviates Skin Dryness, Dry Skin-Induced Itch, and Mechanical Alloknesis. Biomedicines. 2025; 13(3):556. https://doi.org/10.3390/biomedicines13030556
Chicago/Turabian StyleToyama, Sumika, Tomoya Nakamura, Mitsutoshi Tominaga, and Kenji Takamori. 2025. "Topical Application of OJI-204 Alleviates Skin Dryness, Dry Skin-Induced Itch, and Mechanical Alloknesis" Biomedicines 13, no. 3: 556. https://doi.org/10.3390/biomedicines13030556
APA StyleToyama, S., Nakamura, T., Tominaga, M., & Takamori, K. (2025). Topical Application of OJI-204 Alleviates Skin Dryness, Dry Skin-Induced Itch, and Mechanical Alloknesis. Biomedicines, 13(3), 556. https://doi.org/10.3390/biomedicines13030556