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Biomedicines, Volume 12, Issue 5

May 2024 - 205 articles

Cover Story: The fracture of instruments in the root canal (RC) during canal shaping is one of the most common reasons for a negative prognosis. The prevalence of retained fractured endodontic instruments is approximately 1.6%. To address this complication, numerous studies have introduced special instruments and techniques for retrieving obstructing objects with various success rates, as well as potential damage to mechanical root properties. This study, which uses the Nd:YAP laser to remove fractured endodontic instruments, was inspired by observing its effectiveness in cutting metals, and it has the overall aim of creating a safe procedure for future clinical use. View this paper
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Articles (205)

  • Review
  • Open Access
1 Citations
4,329 Views
18 Pages

A Primer for Utilizing Deep Learning and Abdominal MRI Imaging Features to Monitor Autosomal Dominant Polycystic Kidney Disease Progression

  • Chenglin Zhu,
  • Xinzi He,
  • Jon D. Blumenfeld,
  • Zhongxiu Hu,
  • Hreedi Dev,
  • Usama Sattar,
  • Vahid Bazojoo,
  • Arman Sharbatdaran,
  • Mohit Aspal and
  • Dominick Romano
  • + 11 authors

Abdominal imaging of autosomal dominant polycystic kidney disease (ADPKD) has historically focused on detecting complications such as cyst rupture, cyst infection, obstructing renal calculi, and pyelonephritis; discriminating complex cysts from renal...

  • Article
  • Open Access
6 Citations
4,993 Views
12 Pages

Comparative Evaluation of Dental Enamel Microhardness Following Various Methods of Interproximal Reduction: A Vickers Hardness Tester Investigation

  • Dan-Cosmin Serbanoiu,
  • Aurel-Claudiu Vartolomei,
  • Dana-Valentina Ghiga,
  • Silvia Izabella Pop,
  • Irinel Panainte,
  • Marioara Moldovan,
  • Codruta Sarosi,
  • Ioan Petean,
  • Marie-Jose Boileau and
  • Mariana Pacurar

Interproximal enamel reduction, also known as stripping, is a common orthodontic procedure that reduces the mesiodistal diameter of teeth, allowing for a balance of available space in dental arches. The aim of this study was to assess the enamel surf...

  • Article
  • Open Access
8 Citations
5,261 Views
15 Pages

Can Microfluidics Improve Sperm Quality? A Prospective Functional Study

  • Fernando Meseguer,
  • Carla Giménez Rodríguez,
  • Rocío Rivera Egea,
  • Laura Carrión Sisternas,
  • Jose A. Remohí and
  • Marcos Meseguer

The same sperm selection techniques in assisted reproduction clinics have remained largely unchanged despite their weaknesses. Recently, microfluidic devices have emerged as a novel methodology that facilitates the sperm selection process with promis...

  • Article
  • Open Access
6 Citations
2,456 Views
20 Pages

Exploring the Role of Guanylate-Binding Protein-2 in Activated Microglia-Mediated Neuroinflammation and Neuronal Damage

  • Ji-Eun You,
  • Eun-Ji Kim,
  • Ho Won Kim,
  • Jong-Seok Kim,
  • Kyunggon Kim and
  • Pyung-Hwan Kim

Neuron damage by microglia, which act as macrophage cells in the brain, can result in various brain diseases. However, the function of pro-inflammatory or anti-inflammatory microglia in the neurons remains controversial. Guanylate-binding protein-2 (...

  • Review
  • Open Access
21 Citations
8,540 Views
19 Pages

Regulation of the Function and Expression of EpCAM

  • Di Xiao,
  • Mingrui Xiong,
  • Xin Wang,
  • Mengqing Lyu,
  • Hanxiang Sun,
  • Yeting Cui,
  • Chen Chen,
  • Ziyu Jiang and
  • Fan Sun

The epithelial cell adhesion molecule (EpCAM) is a single transmembrane protein on the cell surface. Given its strong expression on epithelial cells and epithelial cell-derived tumors, EpCAM has been identified as a biomarker for circulating tumor ce...

  • Article
  • Open Access
1 Citations
1,981 Views
14 Pages

Characterizing the Dynamic Expression of C1q/TNF-α-Related Protein 6 (CTRP6) during Pregnancy in Humans and Mice with Gestational Diabetes Mellitus

  • Jianan Jiang,
  • Shuangyu Wei,
  • Miao Chen,
  • Yutian Tan,
  • Zhao Yang,
  • Guiying Yang,
  • Weijie Feng,
  • Zhen Han,
  • Xiaojing Wei and
  • Xiao Luo

Aim: C1q/TNF-related protein 6 (CTRP6) is a novel adipokine involved in insulin resistance. Thus, we aim to investigate the expression profile of CTRP6 in the plasma, adipose tissue and placenta of GDM patients and mice. Methods: Chinese Han pregnant...

  • Article
  • Open Access
1,814 Views
11 Pages

Associations of Diabetes and Hyperglycaemia with Extent and Outcomes of Acute Burn Injuries

  • Jeffrey Chandra,
  • Edward Raby,
  • Fiona M. Wood,
  • P. Gerry Fegan and
  • Bu B. Yeap

Background: Severe burns may induce hyperglycaemia in the absence of diabetes, but how glucose trajectories relate to burns outcomes is unclear. Aim: To assess incidence of hyperglycaemia following acute burn injury, and associations with diabetes hi...

  • Article
  • Open Access
5 Citations
3,043 Views
14 Pages

The Influence of Tacrolimus Exposure and Metabolism on the Outcomes of Kidney Transplants

  • Rima Maslauskiene,
  • Ruta Vaiciuniene,
  • Aurelija Radzeviciene,
  • Peteris Tretjakovs,
  • Gita Gersone,
  • Edgaras Stankevicius and
  • Inga Arune Bumblyte

Tacrolimus (TAC) has a narrow therapeutic window and patient-specific pharmacokinetic variability. In our study, we analyzed the association between TAC exposure, metabolism, and kidney graft outcomes (function, rejection, and histological lesions)....

  • Article
  • Open Access
2 Citations
2,532 Views
13 Pages

Insights into Kidney Dysplasia in Duplex Kidneys: From Radiologic Diagnosis to Histopathologic Understanding

  • Dominik Świętoń,
  • Kamil Buczkowski,
  • Piotr Czarniak,
  • Andrzej Gołębiewski,
  • Małgorzata Grzywińska,
  • Mariusz J. Kujawa,
  • Susan J. Back,
  • Maciej Piskunowicz and
  • Ewa Iżycka-Świeszewska

Duplex kidney is a urinary tract anomaly commonly associated with a wide range of primary and secondary parenchymal structural abnormalities. We present a unique comparison of US and MRI findings with histopathology following partial resection of dup...

  • Article
  • Open Access
7 Citations
8,656 Views
22 Pages

An Assessment of Semaglutide Safety Based on Real World Data: From Popularity to Spontaneous Reporting in EudraVigilance Database

  • Anca Butuca,
  • Carmen Maximiliana Dobrea,
  • Anca Maria Arseniu,
  • Adina Frum,
  • Adriana Aurelia Chis,
  • Luca Liviu Rus,
  • Steliana Ghibu,
  • Anca Maria Juncan,
  • Andrei Catalin Muntean and
  • Antonina Evelina Lazăr
  • + 3 authors

Some glucagon-like peptide-1 receptor agonists (GLP-1 RAs), first used in the treatment of type 2 diabetes mellitus (T2DM), have been approved for the treatment of obesity in patients with or without T2DM (liraglutide—LIR, semaglutide—SEM...

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Biomedicines - ISSN 2227-9059