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Review

Vitamin D as an Immunomodulator: Risks with Deficiencies and Benefits of Supplementation

Department of Internal Medicine, University of Michigan, 3116G Taubman Center, SPC 5368, Ann Arbor, MI 48109, USA
Academic Editors: Samir Samman and Ian Darnton-Hill
Healthcare 2015, 3(2), 219-232; https://doi.org/10.3390/healthcare3020219
Received: 15 March 2015 / Revised: 2 April 2015 / Accepted: 8 April 2015 / Published: 14 April 2015
(This article belongs to the Special Issue The Close Relationship: Health and Nutrition)
Vitamin D refers to a class of fat-soluble secosteroids often associated with their role in absorption and metabolism of minerals such as calcium and phosphate. In recent years, our understanding of vitamin D has expanded to include its role in modulating the immune system. Of particular focus are the effects of vitamin D deficiency and supplementation on patients suffering from disorders due to dysregulation of the immune system. In patients with multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease, deficiencies in vitamin D have been associated with an increased risk of disease activity. In this review, we will look at the current state of research in regards to the relationship between vitamin D and immune-dysregulation. We will focus on both the risks associated with vitamin D deficiency as well as the benefits of vitamin D supplementation. View Full-Text
Keywords: vitamin D; immune function; immunomodulator; inflammatory bowel diseases; multiple sclerosis; rheumatoid arthritis; Treg vitamin D; immune function; immunomodulator; inflammatory bowel diseases; multiple sclerosis; rheumatoid arthritis; Treg
MDPI and ACS Style

Goldsmith, J.R. Vitamin D as an Immunomodulator: Risks with Deficiencies and Benefits of Supplementation. Healthcare 2015, 3, 219-232. https://doi.org/10.3390/healthcare3020219

AMA Style

Goldsmith JR. Vitamin D as an Immunomodulator: Risks with Deficiencies and Benefits of Supplementation. Healthcare. 2015; 3(2):219-232. https://doi.org/10.3390/healthcare3020219

Chicago/Turabian Style

Goldsmith, Jason R. 2015. "Vitamin D as an Immunomodulator: Risks with Deficiencies and Benefits of Supplementation" Healthcare 3, no. 2: 219-232. https://doi.org/10.3390/healthcare3020219

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