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Review

Unique Benefits of Tumor-Specific Nanobodies for Fluorescence Guided Surgery

1
Department of Surgery, University of California San Diego, San Diego, CA 92093, USA
2
Department of Surgery, Dana Farber Cancer Center, Boston, MA 02215, USA
3
Department of Surgery, VA San Diego Health Care System, San Diego, CA 92161, USA
4
AntiCancer Inc., San Diego, CA 92111, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Nick Devoogdt
Biomolecules 2021, 11(2), 311; https://doi.org/10.3390/biom11020311
Received: 2 January 2021 / Revised: 11 February 2021 / Accepted: 14 February 2021 / Published: 18 February 2021
(This article belongs to the Special Issue The Therapeutic and Diagnostic Potential of Nanobodies)
Tumor-specific fluorescence labeling is promising for real-time visualization of solid malignancies during surgery. There are a number of technologies to confer tumor-specific fluorescence. Antibodies have traditionally been used due to their versatility in modifications; however, their large size hampers efficient fluorophore delivery. Nanobodies are a novel class of molecules, derived from camelid heavy-chain only antibodies, that have shown promise for tumor-specific fluorescence labeling. Nanobodies are ten times smaller than standard antibodies, while maintaining antigen-binding capacity and have advantageous features, including rapidity of tumor labeling, that are reviewed in the present report. The present report reviews special considerations needed in developing nanobody probes, the status of current literature on the use of nanobody probes in fluorescence guided surgery, and potential challenges to be addressed for clinical translation. View Full-Text
Keywords: fluorescent nanobody; tumor-specific fluorescence; fluorescence-guided surgery fluorescent nanobody; tumor-specific fluorescence; fluorescence-guided surgery
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MDPI and ACS Style

Lwin, T.M.; Hoffman, R.M.; Bouvet, M. Unique Benefits of Tumor-Specific Nanobodies for Fluorescence Guided Surgery. Biomolecules 2021, 11, 311. https://doi.org/10.3390/biom11020311

AMA Style

Lwin TM, Hoffman RM, Bouvet M. Unique Benefits of Tumor-Specific Nanobodies for Fluorescence Guided Surgery. Biomolecules. 2021; 11(2):311. https://doi.org/10.3390/biom11020311

Chicago/Turabian Style

Lwin, Thinzar M., Robert M. Hoffman, and Michael Bouvet. 2021. "Unique Benefits of Tumor-Specific Nanobodies for Fluorescence Guided Surgery" Biomolecules 11, no. 2: 311. https://doi.org/10.3390/biom11020311

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