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Large-Scale Differential Gene Expression Transcriptomic Analysis Identifies a Metabolic Signature Shared by All Cancer Cells

Heterogeneity of Glucose Transport in Lung Cancer

Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(6), 868;
Received: 11 May 2020 / Revised: 28 May 2020 / Accepted: 29 May 2020 / Published: 5 June 2020
(This article belongs to the Special Issue Targeting Tumor Metabolism: From Mechanisms to Therapies)
Increased glucose uptake is a known hallmark of cancer. Cancer cells need glucose for energy production via glycolysis and the tricarboxylic acid cycle, and also to fuel the pentose phosphate pathway, the serine biosynthetic pathway, lipogenesis, and the hexosamine pathway. For this reason, glucose transport inhibition is an emerging new treatment for different malignancies, including lung cancer. However, studies both in animal models and in humans have shown high levels of heterogeneity in the utilization of glucose and other metabolites in cancer, unveiling a complexity that is difficult to target therapeutically. Here, we present an overview of different levels of heterogeneity in glucose uptake and utilization in lung cancer, with diagnostic and therapeutic implications. View Full-Text
Keywords: glucose metabolism; glucose transport; cancer; lung cancer; tumor heterogeneity glucose metabolism; glucose transport; cancer; lung cancer; tumor heterogeneity
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MDPI and ACS Style

Martinez, C.A.; Scafoglio, C. Heterogeneity of Glucose Transport in Lung Cancer. Biomolecules 2020, 10, 868.

AMA Style

Martinez CA, Scafoglio C. Heterogeneity of Glucose Transport in Lung Cancer. Biomolecules. 2020; 10(6):868.

Chicago/Turabian Style

Martinez, Cesar A., and Claudio Scafoglio. 2020. "Heterogeneity of Glucose Transport in Lung Cancer" Biomolecules 10, no. 6: 868.

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