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Metabolites
Volume 12
Issue 11
10.3390/metabo12111094
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Article
Peer-Review Record

Bioactive Efficacy of Novel Carboxylic Acid from Halophilic Pseudomonas aeruginosa against Methicillin-Resistant Staphylococcus aureus

Metabolites 2022, 12(11), 1094; https://doi.org/10.3390/metabo12111094
by Henciya Santhaseelan 1, Vengateshwaran Thasu Dinakaran 1, Balasubramaniyan Sakthivel 2, Maharaja Somasundaram 3, Kaviarasan Thanamegam 1, Velmurugan Devendiran 1, Hans-Uwe Dahms 4,5,6,* and Arthur James Rathinam 1,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Metabolites 2022, 12(11), 1094; https://doi.org/10.3390/metabo12111094
Submission received: 13 October 2022 / Revised: 1 November 2022 / Accepted: 8 November 2022 / Published: 10 November 2022
(This article belongs to the Special Issue Application of Metabolomics in Characterization of Novel Bioactive Natural Products)

Round 1

Reviewer 1 Report

The manuscript is interesting and the current topic is related to the search for new antibacterial substances that are not antibiotics. Nevertheless, I have a few comments:

- I strongly suggest you to proofread English; in some places there are incorrect or colloquial wording and grammatical errors

Abstract: the conclusion is poorly expressed

Saltpan bacteria (lines from 123): a little more information should be introduced regarding the extract used. The authors referred only to the previous article, but it is difficult to assess the properties of the substance used.

Line 328: It is unclear how the authors measured the inhibition zone. The diameter of the well was 6mm, so where did the 0.9mm zone come from?

Line 550: How can virulence be controlled? The authors' actions relate rather to drug resistance.

Minor proofreading notes:

line 326: please fill in µL

line 366: iii- please change the description order

Fig 5 is not clear

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Reviewer 2 Report

I have enjoyed reading manuscript entitled “Bioactive efficacy of Novel Carboxylic acid from Halophilic Pseudomonas aeruginosa against Methicillin resistant Staphylo- 3 coccus aureus.” The problem of AMR is amplifying days by day in developed and developing countries. Discovery of new antibiotics is one of the ways to help cope this alarming situation. The current manuscript has addressed the problem of AMR.

The manuscript has provided all integral components in the methods section. I have only a few comments that could help further polish this manuscript.

 

I would suggest that the authors add precise information about the guidelines with a modified protocol of Buzgaia et al.

 

Is it possible for the authors to discuss in detail the future roadmap regarding commercialization of this product? Are you planning for preclinical studies and clinical trials for this new compound? If yes, what could be the success rate in this regard?

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Round 2

Reviewer 1 Report

I have no any other comments

Reviewer 2 Report

No further comments 

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