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Sci. Pharm.
Volume 82
Issue 4
10.3797/scipharm.1408-05
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Article

Synthesis and Anticancer Activity of New Thiopyrano[2,3-d]thiazoles Based on Cinnamic Acid Amides

by
Andrii LOZYNSKYI,
,
Borys ZIMENKOVSKY
and
Roman LESYK
*
Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010, Lviv, Ukraine
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2014, 82(4), 723-734; https://doi.org/10.3797/scipharm.1408-05
Submission received: 5 August 2014 / Accepted: 15 September 2014 / Published: 15 September 2014
Versions Notes

Abstract

Novel rel-(5R,6S,7S)-2-oxo-5-phenyl-7-aryl(hetaryl)-3,7-dihydro-2H-thiopyrano [2,3-d]thiazole-6-carboxylic acid amides were synthesized in a hetero-Diels-Alder reaction with a series of cinnamic acid amides. The synthesized compounds were tested for their anticancer activity in vitro in the standard National Cancer Institute 60 cancer cell line assay. Promising compounds 3e, 3g, and 3h with moderate antitumor activity were identified among the synthesized series.
Keywords: hetero-Diels-Alder reaction; Cynnamic acid amides; 5-Ylideneisorhodanines; Thiopyrano[2,3-d][1,3]thiazoles; Anticancer activity hetero-Diels-Alder reaction; Cynnamic acid amides; 5-Ylideneisorhodanines; Thiopyrano[2,3-d][1,3]thiazoles; Anticancer activity

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MDPI and ACS Style

LOZYNSKYI,, A.; ZIMENKOVSKY, B.; LESYK, R. Synthesis and Anticancer Activity of New Thiopyrano[2,3-d]thiazoles Based on Cinnamic Acid Amides. Sci. Pharm. 2014, 82, 723-734. https://doi.org/10.3797/scipharm.1408-05

AMA Style

LOZYNSKYI, A, ZIMENKOVSKY B, LESYK R. Synthesis and Anticancer Activity of New Thiopyrano[2,3-d]thiazoles Based on Cinnamic Acid Amides. Scientia Pharmaceutica. 2014; 82(4):723-734. https://doi.org/10.3797/scipharm.1408-05

Chicago/Turabian Style

LOZYNSKYI,, Andrii, Borys ZIMENKOVSKY, and Roman LESYK. 2014. "Synthesis and Anticancer Activity of New Thiopyrano[2,3-d]thiazoles Based on Cinnamic Acid Amides" Scientia Pharmaceutica 82, no. 4: 723-734. https://doi.org/10.3797/scipharm.1408-05

APA Style

LOZYNSKYI,, A., ZIMENKOVSKY, B., & LESYK, R. (2014). Synthesis and Anticancer Activity of New Thiopyrano[2,3-d]thiazoles Based on Cinnamic Acid Amides. Scientia Pharmaceutica, 82(4), 723-734. https://doi.org/10.3797/scipharm.1408-05

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