Synthesis and Characterization of Organic Impurities in Bortezomib Anhydride Produced by a Convergent Technology
F-Synthesis, LLC, Posledniy Per., 11 (1), 107045 Moscow, Russia
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Sci. Pharm. 2012, 80(1), 67-76; https://doi.org/10.3797/scipharm.1109-02
Submission received: 16 September 2011
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Accepted: 1 November 2011
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Published: 1 November 2011
Abstract
A profile of impurities in bortezomib anhydride, produced by a recently developed convergent technology, has been characterized. HPLC-MS analysis of the drug essence revealed three impurities: an epimer of bortezomib, resulting from partial racemization of L-phenylalanine’s stereogenic center during the chemical synthesis, and two epimeric products of oxidative degradation of bortezomib, in which boron is replaced by the OH group. The impurities were obtained by chemical synthesis and characterized by physical methods.
Keywords:
Bortezomib; Chemical synthesis; HPLC; Mass spectrometry; Impurities; Oxidation; Chirality; Velcade
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MDPI and ACS Style
IVANOV, A.S.; SHISHKOV, S.V.; ZHALNINA, A.A. Synthesis and Characterization of Organic Impurities in Bortezomib Anhydride Produced by a Convergent Technology. Sci. Pharm. 2012, 80, 67-76. https://doi.org/10.3797/scipharm.1109-02
AMA Style
IVANOV AS, SHISHKOV SV, ZHALNINA AA. Synthesis and Characterization of Organic Impurities in Bortezomib Anhydride Produced by a Convergent Technology. Scientia Pharmaceutica. 2012; 80(1):67-76. https://doi.org/10.3797/scipharm.1109-02
Chicago/Turabian StyleIVANOV, Andrey S., Sergey V. SHISHKOV, and Anna A. ZHALNINA. 2012. "Synthesis and Characterization of Organic Impurities in Bortezomib Anhydride Produced by a Convergent Technology" Scientia Pharmaceutica 80, no. 1: 67-76. https://doi.org/10.3797/scipharm.1109-02
