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Volume 79
Issue 2
10.3797/scipharm.1010-04
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Article

Study of Thermo-Sensitive In-Situ Gels for Ocular Delivery

by
Manas BHOWMIK
1,*,
Sanchita DAS
1,
Dipankar CHATTOPADHYAY
2 and
Lakshmi K. GHOSH
1
1
Pharmaceutics Research Lab II, Department of Pharmaceutical Technology, Jadavpur University, Kolkata700 032, India
2
Department of Polymer Science & Technology, University College of Science & Technology, 92, A.P.C. Road, University of Calcutta, Kolkata-700 009, India
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2011, 79(2), 351-358; https://doi.org/10.3797/scipharm.1010-04
Submission received: 14 October 2010 / Accepted: 1 March 2011 / Published: 5 March 2011
Versions Notes

Abstract

The aim of the present study was the development of thermo-sensitive in-situ gels for in-vitro evaluation of ophthalmic delivery systems of ketorolac tromethamine (KT), based on methylcellulose (MC) in combination with hydroxypropylmethyl cellulose (HPMC). The gel temperature of 1% MC solution was observed at 60°C. It was found that 6% oral rehydration salt without dextrose (ORS) was capable to reduce the gel temperature below physiological temperature. HPMC was added to increase viscosity and drug release time. The results indicated a large increase in viscosity at 37°C with addition of HPMC whch provided sustained release of the drug over a 4h period. From in-vitro release studies, it could be concluded that the developed systems were thus a better alternative to conventional eye drops.
Keywords: Methylcellulose; Hydroxypropylmethylcellulose; In-situ gel; ORS Methylcellulose; Hydroxypropylmethylcellulose; In-situ gel; ORS

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MDPI and ACS Style

BHOWMIK, M.; DAS, S.; CHATTOPADHYAY, D.; GHOSH, L.K. Study of Thermo-Sensitive In-Situ Gels for Ocular Delivery. Sci. Pharm. 2011, 79, 351-358. https://doi.org/10.3797/scipharm.1010-04

AMA Style

BHOWMIK M, DAS S, CHATTOPADHYAY D, GHOSH LK. Study of Thermo-Sensitive In-Situ Gels for Ocular Delivery. Scientia Pharmaceutica. 2011; 79(2):351-358. https://doi.org/10.3797/scipharm.1010-04

Chicago/Turabian Style

BHOWMIK, Manas, Sanchita DAS, Dipankar CHATTOPADHYAY, and Lakshmi K. GHOSH. 2011. "Study of Thermo-Sensitive In-Situ Gels for Ocular Delivery" Scientia Pharmaceutica 79, no. 2: 351-358. https://doi.org/10.3797/scipharm.1010-04

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