Next Article in Journal
New Selectors Based on Ligand-Exchange for Enantioseparation by Capillary Electrophoresis
Previous Article in Journal
Nanotechnologies for the Delivery of Nucleic Acids and Contrast Agents
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Sci. Pharm.
Volume 77
Issue 5
10.3797/scipharm.oephg.21.PL-05
scipharm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Abstract

From Gene- and Protein Expression Patterns to Biological Mechanisms: -omics in Pharmacology and Toxicology

by
C. GERNER
1,*,
A. SLANY
1,
J. DRACH
1,
T. MOHR
1,
V. PAULITSCHKE
2 and
M. MICKSCHE
1
1
Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, 1090 Vienna, Austria
2
Department of Dermatology, Medical University of Vienna, Währinger Straße 18–20, 1090 Vienna, Austria
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2009, 77(5), 167; https://doi.org/10.3797/scipharm.oephg.21.PL-05
Submission received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
Versions Notes

Abstract

Proteins play a fundamental role in controlling multiple functions within a cell s organization. At pathologic conditions, specifically expressed proteins may indicate disease states and may thus serve as diagnostic markers. Following disease-associated aberrations of protein expression may lead to a better understanding of the mechanisms of diseases and thereby enable the development of new therapeutic strategies. We established a strategy based on the systematic profiling of primary cells which were forced in vitro to enter specific functional states characteristic for certain diseases. Focusing on secreted proteins, we try to identify marker proteins accessible via the blood. Shotgun proteomics proofed to be the method of choice for the identification of low-abundant marker proteins. On the other hand, two-dimensional gel electrophoresis of metabolically labeled cells proofed to be more sensitive to record subtle drug effects. Currently we focus on tumour-stroma interactions resulting in the induced secretion of tumour-promoting survival factors by the stroma cells. We make use of co-culture model systems for testing drugs specifically interfering with this synergistic cell cooperativity.

Share and Cite

MDPI and ACS Style

GERNER, C.; SLANY, A.; DRACH, J.; MOHR, T.; PAULITSCHKE, V.; MICKSCHE, M. From Gene- and Protein Expression Patterns to Biological Mechanisms: -omics in Pharmacology and Toxicology. Sci. Pharm. 2009, 77, 167. https://doi.org/10.3797/scipharm.oephg.21.PL-05

AMA Style

GERNER C, SLANY A, DRACH J, MOHR T, PAULITSCHKE V, MICKSCHE M. From Gene- and Protein Expression Patterns to Biological Mechanisms: -omics in Pharmacology and Toxicology. Scientia Pharmaceutica. 2009; 77(Plenary Lectures (PL)):167. https://doi.org/10.3797/scipharm.oephg.21.PL-05

Chicago/Turabian Style

GERNER, C., A. SLANY, J. DRACH, T. MOHR, V. PAULITSCHKE, and M. MICKSCHE. 2009. "From Gene- and Protein Expression Patterns to Biological Mechanisms: -omics in Pharmacology and Toxicology" Scientia Pharmaceutica 77, Plenary Lectures (PL): 167. https://doi.org/10.3797/scipharm.oephg.21.PL-05

APA Style

GERNER, C., SLANY, A., DRACH, J., MOHR, T., PAULITSCHKE, V., & MICKSCHE, M. (2009). From Gene- and Protein Expression Patterns to Biological Mechanisms: -omics in Pharmacology and Toxicology. Scientia Pharmaceutica, 77(Plenary Lectures (PL)), 167. https://doi.org/10.3797/scipharm.oephg.21.PL-05

Article Metrics

Back to TopTop