Flow Injection Analysis With Trimetazidine Dihydrochloride Ion-Selective Electrode

New Plastic membrane ion-selective electrode for trimetazidine dihydrochloride based on trimetazidinium-tetraphenylborate was prepared. The electrode exhibited mean calibration graph slope of 29.5 mV per decade of (TrimCl₂) concentration at 25°C. The electrode can be used within the concentration range 3.2×10^-5-10^-2 M (TrimCl₂) at pH ranges of 1.5-3.8 and 4.5-7.5. The standard electrode potentials were determined at different temperatures and used to calculate the isothermal coefficient of the electrode, which was (0.00088 V°C^-1). The electrode showed a very good selectivity for (TrimCl₂) with respect to a number of inorganic cations, sugars and amino acids. The electrode was applied to the potentiometric determination of the trimetazidine ion and its pharmaceutical preparation under batch and flow injection conditions. Graphite coated wire was prepared and characterized as sensor for the drug under investigation. Also, trimetazidine was determined by conductimetric titrations.