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Electronics 2019, 8(1), 37; https://doi.org/10.3390/electronics8010037

Design of Electroporation Process in Irregularly Shaped Multicellular Systems

1
Department of Electrical and Information Engineering, Politecnico di Bari, via E. Orabona 4, 70125 Bari, Italy
2
Design Solution Department, Elettronica S.p.A., Via Tiburtina Valeria Km 13,700, 00131 Rome, Italy
3
Department of Bioengineering, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium
4
The Antenna Company Nederland B.V., HighTech Campus 41, 5656 AE Eindhoven, The Netherlands
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 16 November 2018 / Revised: 19 December 2018 / Accepted: 20 December 2018 / Published: 1 January 2019
(This article belongs to the Section Bioelectronics)
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Abstract

Electroporation technique is widely used in biotechnology and medicine for the transport of various molecules through the membranes of biological cells. Different mathematical models of electroporation have been proposed in the literature to study pore formation in plasma and nuclear membranes. These studies are mainly based on models using a single isolated cell with a canonical shape. In this work, a space–time (x,y,t) multiphysics model based on quasi-static Maxwell’s equations and nonlinear Smoluchowski’s equation has been developed to investigate the electroporation phenomenon induced by pulsed electric field in multicellular systems having irregularly shape. The dielectric dispersion of the cell compartments such as nuclear and plasmatic membranes, cytoplasm, nucleoplasm and external medium have been incorporated into the numerical algorithm, too. Moreover, the irregular cell shapes have been modeled by using the Gielis transformations. View Full-Text
Keywords: pulsed electric field; nucleated biological cells; transmembrane voltage; computational model; dielectric dispersion pulsed electric field; nucleated biological cells; transmembrane voltage; computational model; dielectric dispersion
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Mescia, L.; Chiapperino, M.A.; Bia, P.; Lamacchia, C.M.; Gielis, J.; Caratelli, D. Design of Electroporation Process in Irregularly Shaped Multicellular Systems. Electronics 2019, 8, 37.

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