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Open AccessFeature PaperArticle

Development and Characterization of New Topical Hydrogels Based on Alpha Lipoic Acid—Hydrotalcite Hybrids

Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, 06123 Perugia, Italy
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Cosmetics 2019, 6(2), 35; https://doi.org/10.3390/cosmetics6020035
Received: 15 May 2019 / Revised: 13 June 2019 / Accepted: 15 June 2019 / Published: 18 June 2019
(This article belongs to the Special Issue Topical Pharmaceutical Products and Cosmetics)
Alpha lipoic acid (ALA) is a well-known anti-aging compound. The activity of this molecule is limited by two important factors: (i) The low stability to oxidation and thermal processes and (ii) the low solubility. Particularly the latter limits ALA formulation in hydrophilic bases. The purpose of this paper is to present a new technological approach to stabilize lipoic acid in topical hydrogels for cosmetic use. With this aim, ALA was intercalated in two different lamellar anionic clays (hydrotalcites), MgAl and ZnAl, obtaining the hybrids MgAl-ALA and ZnAl-ALA. The intercalation allows to obtain a more manageable product in comparison to raw ALA. After the preliminary characterization, hydrogels containing the hybrids were prepared and characterized, also in comparison to the commercial product Tiobec® in terms of rheological properties, stability to temperature and centrifugation, release, and cytotoxicity. The obtained results highlighted that the hydrogel containing MgAl-ALA is a suitable alternative to the products currently available on the market. View Full-Text
Keywords: lipoic acid; hydrotalcite; intercalation product; hybrids; hydrogel; stability; rheology lipoic acid; hydrotalcite; intercalation product; hybrids; hydrogel; stability; rheology
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MDPI and ACS Style

Pagano, C.; Calarco, P.; Ceccarini, M.R.; Beccari, T.; Ricci, M.; Perioli, L. Development and Characterization of New Topical Hydrogels Based on Alpha Lipoic Acid—Hydrotalcite Hybrids. Cosmetics 2019, 6, 35.

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