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Recent Advances on Topical Application of Ceramides to Restore Barrier Function of Skin

Department of Pharmaceutical Technology, Faculty of Pharmacy, Istanbul University, 34116 Beyazıt, Turkey
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Cosmetics 2019, 6(3), 52; https://doi.org/10.3390/cosmetics6030052
Received: 30 June 2019 / Revised: 16 August 2019 / Accepted: 17 August 2019 / Published: 20 August 2019
(This article belongs to the Special Issue Topical Pharmaceutical Products and Cosmetics)
Human skin is the largest organ of the body and is an effective physical barrier keeping it from environmental conditions. This barrier function of the skin is based on stratum corneum, located in the uppermost skin. Stratum corneum has corneocytes surrounded by multilamellar lipid membranes which are composed of cholesterol, free fatty acids and ceramides (CERs). Alterations in ceramide content of the stratum corneum are associated with numerous skin disorders. In recent years, CERs have been incorporated into conventional and novel carrier systems with the purpose of exogenously applying CERs to help the barrier function of the skin. This review provides an overview of the structure, function and importance of CERs to restore the barrier function of the skin following their topical application. View Full-Text
Keywords: skin barrier; skin disorders; ceramides; topical application skin barrier; skin disorders; ceramides; topical application
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Kahraman, E.; Kaykın, M.; Şahin Bektay, H.; Güngör, S. Recent Advances on Topical Application of Ceramides to Restore Barrier Function of Skin. Cosmetics 2019, 6, 52.

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