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Open AccessFeature PaperArticle

Laser-Assisted Surface Texturing of Ti/Zr Multilayers for Mesenchymal Stem Cell Response

1
Vinča Institute of Nuclear Sciences, University of Belgrade, P.O. Box 522, 11001 Belgrade, Serbia
2
Institute of Electronic Structure and Laser (IESL), Foundation for Research and Technology (FORTH), N. Plastira 100, Vassilika Vouton, 70013 Heraklion, Crete, Greece
3
Jožef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
*
Author to whom correspondence should be addressed.
Coatings 2019, 9(12), 854; https://doi.org/10.3390/coatings9120854
Received: 6 November 2019 / Revised: 9 December 2019 / Accepted: 10 December 2019 / Published: 13 December 2019
(This article belongs to the Special Issue Surface Topography Effects on Functional Properties of PVD Coatings)
The formation of an ordered surface texture with micro and nanometer features on Ti/Zr multilayers is studied for better understanding and improvement of cell integration. Nanocomposite in form 30×(Ti/Zr)/Si thin films was deposited by ion sputtering on Si substrate for biocompatibility investigation. Surface texturing by femtosecond laser processing made it possible to form the laser-induced periodic surface structure (LIPSS) in each laser-written line. At fluence slightly above the ablation threshold, beside the formation of low spatial frequency-LIPSS (LSFL) oriented perpendicular to the direction of the laser polarization, the laser-induced surface oxidation was achieved on the irradiated area. Intermixing between the Ti and Zr layers with the formation of alloy in the sub-surface region was attained during the laser processing. The surface of the Ti/Zr multilayer system with changed composition and topography was used to observe the effect of topography on the survival, adhesion and proliferation of the murine mesenchymal stem cells (MSCs). Confocal and SEM microscopy images showed that cell adhesion and their growth improve on these modified surfaces, with tendency of the cell orientation along of LIPSS in laser-written lines. View Full-Text
Keywords: multilayer thin films; Ti-based alloy; ultrafast laser-modification; cell response multilayer thin films; Ti-based alloy; ultrafast laser-modification; cell response
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MDPI and ACS Style

Petrović, S.; Peruško, D.; Skoulas, E.; Kovač, J.; Mitrić, M.; Potočnik, J.; Rakočević, Z.; Stratakis, E. Laser-Assisted Surface Texturing of Ti/Zr Multilayers for Mesenchymal Stem Cell Response. Coatings 2019, 9, 854.

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