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Uniform and Robust Peptoid Microsphere Coatings

Ralph E. Martin Department of Chemical Engineering, University of Arkansas, 3202 Bell Engineering Center, Fayetteville, AR 72701, USA
Author to whom correspondence should be addressed.
Coatings 2013, 3(2), 98-107;
Received: 21 May 2013 / Revised: 13 June 2013 / Accepted: 14 June 2013 / Published: 21 June 2013
Peptoids that are helical and partially water soluble have been shown to self-assemble into microspheres when the peptoid solution is dried on a silicon substrate. Such microsphere coatings have great potential for use in biosensor technologies, specifically to increase the surface area for binding. However, in order to be useful, the peptoids must consistently form uniform coatings. In this study we investigated the effects of various coating protocol parameters on the uniformity of the resulting peptoid microsphere coatings, including (i) solvent, (ii) administration technique, and (iii) drying environment. In addition, we investigated the robustness of the coatings as well as the potential for using a glass substrate. These studies show that uniform, robust peptoid microsphere coatings can be formed using protic solvents, a full coverage administration technique, and drying in open air on silicon or glass substrates. View Full-Text
Keywords: coating; biosensor; peptoid; microsphere coating; biosensor; peptoid; microsphere
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Hebert, M.L.; Shah, D.S.; Blake, P.; Servoss, S.L. Uniform and Robust Peptoid Microsphere Coatings. Coatings 2013, 3, 98-107.

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