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Article

Antimicrobial Potential of Conjugated Lignin/Morin/Chitosan Combinations as a Function of System Complexity

1
Chemistry Unit, Department of Pharmacology, Animal Physiology, Biochemistry and Chemistry, Faculty of Veterinary Medicine, Trakia University, Students Campus, 6000 Stara Zagora, Bulgaria
2
Department of Biochemistry, Microbiology and Physics, Faculty of Agriculture, Trakia University, Students Campus, 6000 Stara Zagora, Bulgaria
3
Microbiology Unit, Department of Veterinary Microbiology, Infectious and Parasitic Diseases, Faculty of Veterinary Medicine, Trakia University, Students Campus, 6000 Stara Zagora, Bulgaria
4
Department of Chemistry and Biochemistry, Faculty of Medicine, Trakia University, 11 Armeiska Str., 6000 Stara Zagora, Bulgaria
*
Author to whom correspondence should be addressed.
Academic Editor: Marc Maresca
Antibiotics 2022, 11(5), 650; https://doi.org/10.3390/antibiotics11050650
Received: 20 April 2022 / Revised: 5 May 2022 / Accepted: 9 May 2022 / Published: 12 May 2022
(This article belongs to the Special Issue Antimicrobial Activities of Plant Extracts)
As natural biopolymers, chitosan and lignin are characterized by their good biocompatibility, high biodegradability and satisfactory biosafety. The active polymers’ functional groups are responsible for the potential of these biomaterials for use as carrier matrices in the construction of polymer–drug conjugates with prospective applicability in the fields of medicine, food and agriculture—subjects that have attracted attention in recent years. Hence, the aim of this research was to place substantial emphasis on the antimicrobial potential of flavonoid–biopolymer complex systems by assessment of the probable synergetic, additive or antagonistic effects arising as a function of systemic complexity. The joint implementation of morin, chitosan and lignin in conjugated two- and three-component systems provoked species-dependent antimicrobial synergistic and/or potentiation effects against the activity of the tested bacterial strains Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853 and the clinical isolate Bacillus cereus. The double combinations of morin–chitosan and morin–lignin resulted in a 100% increase in their inhibitory activity against S. aureus as compared to the pure biocompounds. The inhibitory effects of the three-component system, in decreasing order, were: S. aureus (IZ = 15.7 mm) > P. aeruginosa (IZ = 15 mm) > B. cereus and E. coli (IZ = 14 mm). All tested morin-containing two- and three-component systems exhibited clear and significant potentiation effects, especially against S. aureus and B. cereus. The results obtained are a prerequisite for the potential use of the studied conjugated lignin–morin–chitosan combinations in the construction of novel drug-carrier formulations with improved bioactivities. View Full-Text
Keywords: morin; chitosan; lignin; antibacterial activity; combined systems morin; chitosan; lignin; antibacterial activity; combined systems
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MDPI and ACS Style

Yaneva, Z.; Beev, G.; Rusenova, N.; Ivanova, D.; Tzanova, M.; Stoeva, D.; Toneva, M. Antimicrobial Potential of Conjugated Lignin/Morin/Chitosan Combinations as a Function of System Complexity. Antibiotics 2022, 11, 650. https://doi.org/10.3390/antibiotics11050650

AMA Style

Yaneva Z, Beev G, Rusenova N, Ivanova D, Tzanova M, Stoeva D, Toneva M. Antimicrobial Potential of Conjugated Lignin/Morin/Chitosan Combinations as a Function of System Complexity. Antibiotics. 2022; 11(5):650. https://doi.org/10.3390/antibiotics11050650

Chicago/Turabian Style

Yaneva, Zvezdelina, Georgi Beev, Nikolina Rusenova, Donika Ivanova, Milena Tzanova, Daniela Stoeva, and Monika Toneva. 2022. "Antimicrobial Potential of Conjugated Lignin/Morin/Chitosan Combinations as a Function of System Complexity" Antibiotics 11, no. 5: 650. https://doi.org/10.3390/antibiotics11050650

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