Next Article in Journal
Epoxidation of Carbon Nanocapsules: Decoration of Single-Walled Carbon Nanotubes Filled with Metal Halides
Previous Article in Journal
Three-Dimensional SnS Decorated Carbon Nano-Networks as Anode Materials for Lithium and Sodium Ion Batteries
Open AccessArticle

Morphology-Variable Aggregates Prepared from Cholesterol-Containing Amphiphilic Glycopolymers: Their Protein Recognition/Adsorption and Drug Delivery Applications

by Zhao Wang 1,2, Ting Luo 2, Amin Cao 2,*, Jingjing Sun 2, Lin Jia 1,2,* and Ruilong Sheng 2,3,*
1
Department of Polymer Materials, Shanghai University, 99 Shangda Road, Mailbox 152, Shanghai 200444, China
2
CAS Key Laboratory of Synthetic and Self-assembly Chemistry for Organic Functional Molecules, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
3
CQM—Centro de Química da Madeira, Universidade da Madeira, Campus da Penteada, 9000-390 Funchal, Portugal
*
Authors to whom correspondence should be addressed.
Nanomaterials 2018, 8(3), 136; https://doi.org/10.3390/nano8030136
Received: 17 January 2018 / Revised: 22 February 2018 / Accepted: 24 February 2018 / Published: 28 February 2018
In this study, a series of diblock glycopolymers, poly(6-O-methacryloyl-d-galactopyranose)-b-poly(6-cholesteryloxyhexyl methacrylate) (PMAgala-b-PMAChols), with cholesterol/galactose grafts were prepared through a sequential reversible addition-fragmentation chain transfer (RAFT) polymerization and deprotection process. The glycopolymers could self-assemble into aggregates with various morphologies depending on cholesterol/galactose-containing block weight ratios, as determined by transmission electronic microscopy (TEM) and dynamic laser light scattering (DLS). In addition, the lectin (Ricinus communis agglutinin II, RCA120) recognition and bovine serum albumin (BSA) adsorption of the PMAgala-b-PMAChol aggregates were evaluated. The SK-Hep-1 tumor cell inhibition properties of the PMAgala-b-PMAChol/doxorubicin (DOX) complex aggregates were further examined in vitro. Results indicate that the PMAgala-b-PMAChol aggregates with various morphologies showed different interaction/recognition features with RCA120 and BSA. Spherical aggregates (d ≈ 92 nm) possessed the highest RCA120 recognition ability and lowest BSA protein adsorption. In addition, the DOX-loaded spherical complex aggregates exhibited a better tumor cell inhibition property than those of nanofibrous complex aggregates. The morphology-variable aggregates derived from the amphiphilic glycopolymers may serve as multifunctional biomaterials with biomolecular recognition and drug delivery features. View Full-Text
Keywords: cholesterol; galactose; morphology; lectin recognition; DOX delivery cholesterol; galactose; morphology; lectin recognition; DOX delivery
Show Figures

Graphical abstract

MDPI and ACS Style

Wang, Z.; Luo, T.; Cao, A.; Sun, J.; Jia, L.; Sheng, R. Morphology-Variable Aggregates Prepared from Cholesterol-Containing Amphiphilic Glycopolymers: Their Protein Recognition/Adsorption and Drug Delivery Applications. Nanomaterials 2018, 8, 136.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop