Next Article in Journal
Simultaneous Dual-mode Emission and Tunable Multicolor in the Time Domain from Lanthanide-doped Core-shell Microcrystals
Previous Article in Journal
Self-Powered Wearable Pressure Sensors with Enhanced Piezoelectric Properties of Aligned P(VDF-TrFE)/MWCNT Composites for Monitoring Human Physiological and Muscle Motion Signs
Previous Article in Special Issue
Nanoemulsion-Enabled Oral Delivery of Novel Anticancer ω-3 Fatty Acid Derivatives
Open AccessArticle

Development of Pranoprofen Loaded Nanostructured Lipid Carriers to Improve Its Release and Therapeutic Efficacy in Skin Inflammatory Disorders

1
Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain
2
Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, 08028 Barcelona, Spain
3
Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain
4
Institute of Biomedicine, University of Barcelona, 08028 Barcelona, Spain
5
Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Cuernavaca 62000, Morelos, Mexico
6
Institut de Recerca en Nutrició i Seguretat Alimentària (INSA), Universitat de Barcelona (UB), 08921 Santa Coloma del Gramanet Barcelona, Spain
7
Department of Chemical and Instrumental Analysis, Faculty of Chemistry and Pharmacy, University of El Salvador, Ciudad Universitaria, 3026 San Salvador, El Salvador
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nanomaterials 2018, 8(12), 1022; https://doi.org/10.3390/nano8121022
Received: 31 October 2018 / Revised: 24 November 2018 / Accepted: 1 December 2018 / Published: 7 December 2018
(This article belongs to the Special Issue Pharmaceutical Nanotechnology)
Pranoprofen (PF)-loaded nanostructured lipid carriers (NLCs), prepared using a high-pressure homogenization method, have been optimized and characterized to improve the biopharmaceutical profile of the drug. The optimized PF-NLCs exhibited physicochemical characteristics and morphological properties that were suitable for dermal application. Stability assays revealed good physical stability, and the release behavior of PF from these NLCs showed a sustained release pattern. Cell viability results revealed no toxicity. Ex vivo human skin permeation studies in Franz diffusion cells were performed to determine the influence of different skin penetration enhancers (pyrrolidone, decanol, octanoic acid, nonane, menthone, squalene, linoleic acid, and cineol) on skin penetration and retention of PF, being the highest dermal retention in the presence of linoleic acid. The selected formulations of NLCs exhibited a high retained amount of PF in the skin and no systemic effects. In vivo mice anti-inflammatory efficacy studies showed a significant reduction in dermal oedema. NLCs containing linoleic acid presented better anti-inflammatory efficacy by decreasing the production of interleukins in keratinocytes and monocytes. The biomechanical properties of skin revealed an occlusive effect and no hydration power. No signs of skin irritancy in vivo were detected. According to these results, dermal PF-NLCs could be an effective system for the delivery and controlled release of PF, improving its dermal retention, with reduced dermal oedema as a possible effect of this drug. View Full-Text
Keywords: pranoprofen; nanostructured lipid carriers; penetration enhancers; linoleic acid; skin delivery; anti-inflammatory activity pranoprofen; nanostructured lipid carriers; penetration enhancers; linoleic acid; skin delivery; anti-inflammatory activity
Show Figures

Graphical abstract

MDPI and ACS Style

Rincón, M.; Calpena, A.C.; Fabrega, M.-J.; Garduño-Ramírez, M.L.; Espina, M.; Rodríguez-Lagunas, M.J.; García, M.L.; Abrego, G. Development of Pranoprofen Loaded Nanostructured Lipid Carriers to Improve Its Release and Therapeutic Efficacy in Skin Inflammatory Disorders. Nanomaterials 2018, 8, 1022.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop