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Open AccessReview

Pro-Inflammatory Versus Anti-Inflammatory Effects of Dendrimers: The Two Faces of Immuno-Modulatory Nanoparticles

by Séverine Fruchon 1,2 and Rémy Poupot 1,2,*
1
INSERM, U1043, Centre de Physiopathologie de Toulouse-Purpan, Université de Toulouse, F-31300 Toulouse, France
2
CNRS, U5282, F-31300 Toulouse, France
*
Author to whom correspondence should be addressed.
Nanomaterials 2017, 7(9), 251; https://doi.org/10.3390/nano7090251
Received: 21 July 2017 / Revised: 25 August 2017 / Accepted: 30 August 2017 / Published: 1 September 2017
(This article belongs to the Special Issue Nanoparticles in Immunology)
Dendrimers are soft matter, hyperbranched, and multivalent nanoparticles whose synthesis theoretically affords monodisperse compounds. They are built from a core on which one or several successive series of branches are engrafted in an arborescent way. At the end of the synthesis, the tunable addition of surface groups gives birth to multivalent nano-objects which are generally intended for a specific use. For these reasons, dendrimers have received a lot of attention from biomedical researchers. In particular, some of us have demonstrated that dendrimers can be intrinsically drug-candidate for the treatment of inflammatory disorders, amongst others, using relevant preclinical animal models. These anti-inflammatory dendrimers are innovative in the pharmaceutical field. More recently, it has appeared that some dendrimers (even among those which have been described as anti-inflammatory) can promote inflammatory responses in non-diseased animals. The main corpus of this concise review is focused on the reports which describe anti-inflammatory properties of dendrimers in vivo, following which we review the few recent articles that show pro-inflammatory effects of our favorite molecules, to finally discuss this duality in immuno-modulation which has to be taken into account for the preclinical and clinical developments of dendrimers. View Full-Text
Keywords: dendrimers; nanoparticles; inflammation; immuno-safety dendrimers; nanoparticles; inflammation; immuno-safety
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Fruchon, S.; Poupot, R. Pro-Inflammatory Versus Anti-Inflammatory Effects of Dendrimers: The Two Faces of Immuno-Modulatory Nanoparticles. Nanomaterials 2017, 7, 251.

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