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Article

Enhanced Antibacterial Activity of Echinacea angustifolia Extract against Multidrug-Resistant Klebsiella pneumoniae through Niosome Encapsulation

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School of Chemical Engineering, College of Engineering, University of Tehran, Tehran 1417935840, Iran
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Department of Biology, Parand Branch, Islamic Azad University, Parand 3761396361, Iran
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Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran 1996835113, Iran
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Department of Chemical and Petrochemical Engineering, Sharif University of Technology, Tehran 1458889694, Iran
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Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran 1477893855, Iran
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Department of Biology, Roudehen Branch, Islamic Azad University, Roudehen 3973188981, Iran
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Laboratory for Biointerfaces, Empa, Swiss Federal Laboratories for Materials Science and Technology, 9014 St. Gallen, Switzerland
*
Authors to whom correspondence should be addressed.
Academic Editor: Alexey Pestryakov
Nanomaterials 2021, 11(6), 1573; https://doi.org/10.3390/nano11061573
Received: 23 April 2021 / Revised: 30 May 2021 / Accepted: 3 June 2021 / Published: 15 June 2021
With the increased occurrence of antibiotic-resistant bacteria, alternatives to classical antibiotics are urgently needed for treatment of various infectious diseases. Medicinal plant extracts are among the promising candidates due to their bioactive components. The aim of this study was to prepare niosome-encapsulated Echinacea angustifolia extract and study its efficacy against multidrug-resistant Klebsiella pneumoniae strains. Encapsulation was first optimized by Design of Experiments, followed by the empirical study. The obtained niosomes were further characterized for the size and morphology using dynamic light scattering (DLS), transmission electron microscopy (TEM), and scanning electron microscopy (SEM). Spherical niosomes had a diameter of 142.3 ± 5.1 nm, as measured by DLS. The entrapment efficiency (EE%) of E. angustifolia extract reached up to 77.1% ± 0.3%. The prepared niosomes showed a controlled drug release within the tested 72 h and a storage stability of at least 2 months at both 4 and 25 °C. The encapsulated E. angustifolia displayed up to 16-fold higher antibacterial activity against multidrug-resistant K.pneumoniae strains, compared to the free extract. Additionally, the niosome exhibited negligible cytotoxicity against human foreskin fibroblasts. We anticipate that the results presented herein could contribute to the preparation of other plant extracts with improved stability and antibacterial activity, and will help reduce the overuse of antibiotics by controlled release of natural-derived drugs. View Full-Text
Keywords: Echinacea angustifolia; niosome; encapsulation; antibacterial activity; stability; drug delivery Echinacea angustifolia; niosome; encapsulation; antibacterial activity; stability; drug delivery
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MDPI and ACS Style

Moghtaderi, M.; Mirzaie, A.; Zabet, N.; Moammeri, A.; Mansoori-Kermani, A.; Akbarzadeh, I.; Eshrati Yeganeh, F.; Chitgarzadeh, A.; Bagheri Kashtali, A.; Ren, Q. Enhanced Antibacterial Activity of Echinacea angustifolia Extract against Multidrug-Resistant Klebsiella pneumoniae through Niosome Encapsulation. Nanomaterials 2021, 11, 1573. https://doi.org/10.3390/nano11061573

AMA Style

Moghtaderi M, Mirzaie A, Zabet N, Moammeri A, Mansoori-Kermani A, Akbarzadeh I, Eshrati Yeganeh F, Chitgarzadeh A, Bagheri Kashtali A, Ren Q. Enhanced Antibacterial Activity of Echinacea angustifolia Extract against Multidrug-Resistant Klebsiella pneumoniae through Niosome Encapsulation. Nanomaterials. 2021; 11(6):1573. https://doi.org/10.3390/nano11061573

Chicago/Turabian Style

Moghtaderi, Maryam, Amir Mirzaie, Negar Zabet, Ali Moammeri, Amirreza Mansoori-Kermani, Iman Akbarzadeh, Faten Eshrati Yeganeh, Arman Chitgarzadeh, Aliasghar Bagheri Kashtali, and Qun Ren. 2021. "Enhanced Antibacterial Activity of Echinacea angustifolia Extract against Multidrug-Resistant Klebsiella pneumoniae through Niosome Encapsulation" Nanomaterials 11, no. 6: 1573. https://doi.org/10.3390/nano11061573

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