Next Article in Journal
Perfect Absorption and Refractive-Index Sensing by Metasurfaces Composed of Cross-Shaped Hole Arrays in Metal Substrate
Next Article in Special Issue
Spin-Resolved Quantum Scars in Confined Spin-Coupled Two-Dimensional Electron Gas
Previous Article in Journal
Alzheimer’s Disease: An Overview of Major Hypotheses and Therapeutic Options in Nanotechnology
Previous Article in Special Issue
Exploring the Different Degrees of Magnetic Disorder in TbxR1−xCu2 Nanoparticle Alloys
Communication

Uncovering the Magnetic Particle Imaging and Magnetic Resonance Imaging Features of Iron Oxide Nanocube Clusters

1
Istituto Italiano di Tecnologia, via Morego 30, 16163 Genoa, Italy
2
Department of Chemistry, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
3
Department of Materials Science and Engineering, University of Sheffield, Sheffield S10 2 TN, UK
*
Authors to whom correspondence should be addressed.
Nanomaterials 2021, 11(1), 62; https://doi.org/10.3390/nano11010062
Received: 4 December 2020 / Revised: 23 December 2020 / Accepted: 24 December 2020 / Published: 29 December 2020
(This article belongs to the Special Issue Interactions Effects in Nanoscaled Magnetic Assemblies)
Multifunctional imaging nanoprobes continue to garner strong interest for their great potential in the detection and monitoring of cancer. In this study, we investigate a series of spatially arranged iron oxide nanocube-based clusters (i.e., chain-like dimer/trimer, centrosymmetric clusters, and enzymatically cleavable two-dimensional clusters) as magnetic particle imaging and magnetic resonance imaging probes. Our findings demonstrate that the short nanocube chain assemblies exhibit remarkable magnetic particle imaging signal enhancement with respect to the individually dispersed or the centrosymmetric cluster analogues. This result can be attributed to the beneficial uniaxial magnetic dipolar coupling occurring in the chain-like nanocube assembly. Moreover, we could effectively synthesize enzymatically cleavable two-dimensional nanocube clusters, which upon exposure to a lytic enzyme, exhibit a progressive increase in magnetic particle imaging signal at well-defined incubation time points. The increase in magnetic particle imaging signal can be used to trace the disassembly of the large planar clusters into smaller nanocube chains by enzymatic polymer degradation. These studies demonstrate that chain-like assemblies of iron oxide nanocubes offer the best spatial arrangement to improve magnetic particle imaging signals. In addition, the nanocube clusters synthesized in this study also show remarkable transverse magnetic resonance imaging relaxation signals. These nanoprobes, previously showcased for their outstanding heat performance in magnetic hyperthermia applications, have great potential as dual imaging probes and could be employed to improve the tumor thermo-therapeutic efficacy, while offering a readable magnetic signal for image mapping of material disassemblies at tumor sites. View Full-Text
Keywords: iron oxide nanocubes; nanoclusters; magnetic particle imaging; magnetic resonance imaging; enzymatic responsive materials; 2D-Clusters; nanochains; magnetic beads iron oxide nanocubes; nanoclusters; magnetic particle imaging; magnetic resonance imaging; enzymatic responsive materials; 2D-Clusters; nanochains; magnetic beads
Show Figures

Graphical abstract

MDPI and ACS Style

Avugadda, S.K.; Wickramasinghe, S.; Niculaes, D.; Ju, M.; Lak, A.; Silvestri, N.; Nitti, S.; Roy, I.; Samia, A.C.S.; Pellegrino, T. Uncovering the Magnetic Particle Imaging and Magnetic Resonance Imaging Features of Iron Oxide Nanocube Clusters. Nanomaterials 2021, 11, 62. https://doi.org/10.3390/nano11010062

AMA Style

Avugadda SK, Wickramasinghe S, Niculaes D, Ju M, Lak A, Silvestri N, Nitti S, Roy I, Samia ACS, Pellegrino T. Uncovering the Magnetic Particle Imaging and Magnetic Resonance Imaging Features of Iron Oxide Nanocube Clusters. Nanomaterials. 2021; 11(1):62. https://doi.org/10.3390/nano11010062

Chicago/Turabian Style

Avugadda, Sahitya K., Sameera Wickramasinghe, Dina Niculaes, Minseon Ju, Aidin Lak, Niccolò Silvestri, Simone Nitti, Ipsita Roy, Anna C.S. Samia, and Teresa Pellegrino. 2021. "Uncovering the Magnetic Particle Imaging and Magnetic Resonance Imaging Features of Iron Oxide Nanocube Clusters" Nanomaterials 11, no. 1: 62. https://doi.org/10.3390/nano11010062

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop