A Novel Multi-Phosphonate Surface Treatment of Titanium Dental Implants: A Study in Sheep
by
Marcella Von Salis-Soglio 1, Stefan Stübinger 1,2, Michéle Sidler 1,3, Karina Klein 1, Stephen J. Ferguson 4, Käthi Kämpf 1, Katalin Zlinszky 1, Sabrina Buchini 5, Richard Curno 5, Péter Péchy 5, Bjorn-Owe Aronsson 5 and Brigitte Von Rechenberg 1,*
Marcella Von Salis-Soglio 1, Stefan Stübinger 1,2, Michéle Sidler 1,3, Karina Klein 1, Stephen J. Ferguson 4, Käthi Kämpf 1, Katalin Zlinszky 1, Sabrina Buchini 5, Richard Curno 5, Péter Péchy 5, Bjorn-Owe Aronsson 5 and Brigitte Von Rechenberg 1,*
1
Musculoskeletal Research Unit, Equine Hospital, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, Zürich 8057, Switzerland
2
Center of Applied Biotechnology and Molecular Medicine (CABMM), Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 190, Zürich 8057, Switzerland
3
Veterinary Anaesthesia Services Int (VAS), Zürcherstrasse 39, Winterthur 8400, Switzerland
4
Institute for Biomechanics, ETH Zürich, Vladimir-Prelog-Weg 1-5/10, Zürich 8093, Switzerland
5
Nano Bridging Molecules SA, Rte Cité Ouest 2, Gland 1196, Switzerland
*
Author to whom correspondence should be addressed.
J. Funct. Biomater. 2014, 5(3), 135-157; https://doi.org/10.3390/jfb5030135
Received: 10 July 2014 / Revised: 20 August 2014 / Accepted: 2 September 2014 / Published: 11 September 2014
(This article belongs to the Special Issue Coating Deposition and Surface Functionalization of Implants for Biomedical Applications 2014)
The aim of the present study was to evaluate a new multi-phosphonate surface treatment (SurfLink®) in an unloaded sheep model. Treated implants were compared to control implants in terms of bone to implant contact (BIC), bone formation, and biomechanical stability. The study used two types of implants (rough or machined surface finish) each with either the multi-phosphonate Wet or Dry treatment or no treatment (control) for a total of six groups. Animals were sacrificed after 2, 8, and 52 weeks. No adverse events were observed at any time point. At two weeks, removal torque showed significantly higher values for the multi-phosphonate treated rough surface (+32% and +29%, Dry and Wet, respectively) compared to rough control. At 52 weeks, a significantly higher removal torque was observed for the multi-phosphonate treated machined surfaces (+37% and 23%, Dry and Wet, respectively). The multi-phosphonate treated groups showed a positive tendency for higher BIC with time and increased new-old bone ratio at eight weeks. SEM images revealed greater amounts of organic materials on the multi-phosphonate treated compared to control implants, with the bone fracture (from the torque test) appearing within the bone rather than at the bone to implant interface as it occurred for control implants.
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Keywords:
surface treatment; multi-phosphonate; bone formation; removal torque test; bone-to-implant-contact; scanning electron microscopy; osseointegration
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This is an open access article distributed under the Creative Commons Attribution License
MDPI and ACS Style
Von Salis-Soglio, M.; Stübinger, S.; Sidler, M.; Klein, K.; Ferguson, S.J.; Kämpf, K.; Zlinszky, K.; Buchini, S.; Curno, R.; Péchy, P.; Aronsson, B.-O.; Von Rechenberg, B. A Novel Multi-Phosphonate Surface Treatment of Titanium Dental Implants: A Study in Sheep. J. Funct. Biomater. 2014, 5, 135-157.
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