Next Article in Journal
Anabolic Actions of the Regenerative Agent Enamel Matrix Derivative (EMD) in Oral Periosteal Fibroblasts and MG 63 Osteoblasts, Modulation by Nicotine and Glutathione in a Redox Environment
Next Article in Special Issue
Soft Polymers for Building up Small and Smallest Blood Supplying Systems by Stereolithography
Previous Article in Journal
Preparation and Functional Assessment of Composite Chitosan-Nano-Hydroxyapatite Scaffolds for Bone Regeneration
Previous Article in Special Issue
A Path to Soluble Molecularly Imprinted Polymers
Article Menu

Export Article

Open AccessArticle
J. Funct. Biomater. 2012, 3(1), 131-142;

Synthesis and Evaluation of a Molecularly Imprinted Polymer for Selective Solid-Phase Extraction of Irinotecan from Human Serum Samples

Institut des Biomolécules Max Mousseron, Université Montpellier 2, UMR 5247 CNRS-UM1-UM2, case courrier 1705, Place Eugène Bataillon, Montpellier Cedex 05 F-34095, France
Laboratoire de Ciblage Thérapeutique en Cancérologie, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre Bénite F-69495, France
Laboratoire de Cytologie Analytique, Inserm U590, Université Lyon 1, Lyon F-69008, France
Author to whom correspondence should be addressed.
Received: 12 January 2012 / Revised: 11 February 2012 / Accepted: 11 February 2012 / Published: 20 February 2012
(This article belongs to the Special Issue Molecularly Imprinted Polymers in Biomedical Applications)
Full-Text   |   PDF [781 KB, uploaded 21 February 2012]   |  


A molecularly imprinted polymer (MIP) was synthesized by non-covalent imprinting polymerization using irinotecan as template. Methacrylic acid and 4-vinylpyridine were selected as functional monomers. An optimized procedure coupled to LC-PDA analysis was developed for the selective solid-phase extraction of irinotecan from various organic media. A specific capacity of 0.65 µmol•g−1 for the MIP was determined. The high specificity of this MIP was demonstrated by studying the retention behaviour of two related compounds, camptothecin and SN-38. This support was applied for the extraction of irinotecan from human serum samples. View Full-Text
Keywords: molecularly imprinted polymer; irinotecan; human serum; LC-PDA molecularly imprinted polymer; irinotecan; human serum; LC-PDA

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Roy, B.; Vo Duy, S.; Puy, J.-Y.; Martin, C.; Guitton, J.; Dumontet, C.; Périgaud, C.; Lefebvre-Tournier, I. Synthesis and Evaluation of a Molecularly Imprinted Polymer for Selective Solid-Phase Extraction of Irinotecan from Human Serum Samples. J. Funct. Biomater. 2012, 3, 131-142.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top