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J. Clin. Med. 2019, 8(1), 90; https://doi.org/10.3390/jcm8010090

Probiotic Lactobacillus spp. Act Against Helicobacter pylori-induced Inflammation

1
Research and Development Department, GenMont Biotech Incorporation, Tainan 74144, Taiwan
2
Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, Chang Gung University, Taoyuan 33302, Taiwan
3
Department of Laboratory Medicine, Taichung Veterans General Hospital Chiayi Branch, Chiayi 60090, Taiwan
4
Department of Medical Research, Graduate Institute of Biomedical Sciences, China Medical University and Hospital, Taichung 40202, Taiwan
5
Department of Biomedical Sciences, Department of Medical Research, Chung Shan Medical University and Hospital, Taichung 40201, Taiwan
6
Department of Medical Biotechnology and Laboratory Science, Microbiota Research Center, Chang Gung University, Gueishan 33302, Taiwan
7
Molecular Infectious Disease Research Center, Department of Pediatrics, Department of Laboratory Medicine, Chang Gung Memorial Hospital, Linkou 33305, Taiwan
8
Department of Pharmacy, National Yan-Ming University, Taipei 11221, Taiwan
9
Department of Nursing, Asia University, Taichung 41354, Taiwan
The authors have contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 25 December 2018 / Revised: 4 January 2019 / Accepted: 8 January 2019 / Published: 14 January 2019
(This article belongs to the Special Issue Helicobacter pylori Infection and Gastritis)
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Abstract

The bacterial species, Helicobacter pylori, is associated with several gastrointestinal diseases, and poses serious health threats owing to its resistance to antibiotics. Lactobacillus spp., on the other hand, possess probiotic activities that have beneficial effects in humans. However, the mechanisms by which Lactobacillus spp. harbor favorable functions and act against H. pylori infection remain to be explored. The aim of this study was to investigate the ability of bacterial strains, Lactobacillus rhamnosus and Lactobacillus acidophilus, termed GMNL-74 and GMNL-185, respectively, to inhibit H. pylori growth and inflammation. Our results showed that GMNL-74 and GMNL-185 possess potent antimicrobial activity against multidrug resistant (MDR)-H. pylori. In addition, an in vitro cell-based model revealed that the inhibition of H. pylori adhesion and invasion of gastric epithelial cells and interleukin-8 production were significantly decreased by treatment with both the Lactobacillus strains. In vivo studies demonstrated that colonization of H. pylori and induced inflammation in the mouse stomach were also alleviated by these Lactobacillus strains. Furthermore, the abundance of beneficial gut bacteria, including Bifidobacterium spp. and Akkermansia muciniphilia, were significantly increased in H. pylori-infected mice treated with GMNL-74 and GMNL-185. These results demonstrate that Lactobacillus spp. ameliorate H. pylori-induced inflammation and supports beneficial gut specific bacteria that act against H. pylori infection. View Full-Text
Keywords: Helicobacter pylori; Lactobacillus; probiotic; inflammation Helicobacter pylori; Lactobacillus; probiotic; inflammation
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Chen, Y.-H.; Tsai, W.-H.; Wu, H.-Y.; Chen, C.-Y.; Yeh, W.-L.; Chen, Y.-H.; Hsu, H.-Y.; Chen, W.-W.; Chen, Y.-W.; Chang, W.-W.; Lin, T.-L.; Lai, H.-C.; Lin, Y.-H.; Lai, C.-H. Probiotic Lactobacillus spp. Act Against Helicobacter pylori-induced Inflammation. J. Clin. Med. 2019, 8, 90.

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