Effect of Topical Prostaglandin Analogue Therapy on Central Corneal Thickness: A Systematic Review

Round 1

Reviewer 1 Report

In this review the authors discuss the effect of PGAs on the central corneal thickness. Below are my remarks:

Lines 267-272: The authors state:” In a previous cross-sectional study of OHTS, CCT decreased by 0.63μm per year, while that in a subsequent 3.8-year retrospective study, decreased by 0.74±0.35μm per year.[27]” In which study did the CCY decreased by 0.633m per year? Viswanathan et al. (2013) (ref 28) compared a group of patients receiving PGA or PGA/b-blockers with a control group of glaucoma suspects who did not receive any medication. The authors need to clarify to which studies they refer and discuss in further detail ref 28

This review contains a lit of information on the effect of PGAs on CCT, it is well presented and adequately discussed. The methodology is clearly written

Author Response

Thank you for reviewing this manuscript and for giving pertinent comments and suggestions.    Lines 267-272:” In a previous cross-sectional study of OHTS, CCT decreased by 0.63μm per year, while that in a subsequent 3.8-year retrospective study, decreased by 0.74±0.35μm per year [27].”  I am missing a reference in this sentence. “A previous cross-sectional study of OHTS” reporting a CCT reduction of 0.63 μm per year was written by Brandt et al. (2001), “Central corneal thickness in the Ocular Hypertension Study (OHTS).”. I will edit the text by adding this reference.

Reviewer 2 Report

Kim & Yim provide a systematic review of an important topic -- CCT changes with topical prostaglandin analogue therapy. The report is well-designed, well-written, and adequately describes the current body of work in this area. 

I have no editorial comments but want to encourage the authors to:

1. Place the [ ] for references inside the sentences (e.g., for line 36, should read "....outflow [1-5].")

2. Why separate the Google search (in line 74) from the rest?

Interesting paper. Thanks for allowing me to review it.

Author Response

Thank you for reviewing this manuscript and for giving pertinent comments and suggestions.

 First, I moved all periods outside the references so that all references are included within sentences.   

  Second, according to PRISMA 2020, it was recommended that search results by other methods besides database search be reported separately. Therefore, I separately mentioned the website search conducted through Google. Considering the overall context, it seems more appropriate to change the wording from "through Google search result" to "through Website search result (Google)", and I'll edit it.