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Open AccessArticle

Precipitation of Inorganic Salts in Mitochondrial Matrix

1
Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Al. Mickiewicza 30, 30-059 Krakow, Poland
2
Department of Physics and Biophysics, Warsaw University of Life Sciences—SGGW, Nowoursynowska 159, 02-776 Warszawa, Poland
3
Johan Gadolin Process Chemistry Centre, Centre of Process Analytical Chemistry and Sensor Technology (ProSens), Åbo Akademi University, Biskopsgatan 8, 20500 Åbo-Turku, Finland
*
Author to whom correspondence should be addressed.
Membranes 2020, 10(5), 81; https://doi.org/10.3390/membranes10050081
Received: 26 March 2020 / Revised: 17 April 2020 / Accepted: 19 April 2020 / Published: 27 April 2020
In the mitochondrial matrix, there are insoluble, osmotically inactive complexes that maintain a constant pH and calcium concentration. In the present paper, we examine the properties of insoluble calcium and magnesium salts, such as phosphates, carbonates and polyphosphates, which might play this role. We find that non-stoichiometric, magnesium-rich carbonated apatite, with very low crystallinity, precipitates in the matrix under physiological conditions. Precipitated salt acts as pH buffer, and, hence, can contribute in maintaining ATP production in ischemic conditions, which delays irreversible damage to heart and brain cells after stroke. View Full-Text
Keywords: mitochondrion; calcium carbonates; calcium phosphates; calcium polyphosphates; ATP production; hypoxia; ischemia; pre-conditioning mitochondrion; calcium carbonates; calcium phosphates; calcium polyphosphates; ATP production; hypoxia; ischemia; pre-conditioning
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MDPI and ACS Style

Jasielec, J.J.; Filipek, R.; Dołowy, K.; Lewenstam, A. Precipitation of Inorganic Salts in Mitochondrial Matrix. Membranes 2020, 10, 81.

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