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Pandemic Influenza Vaccines: What did We Learn from the 2009 Pandemic and are We Better Prepared Now?

by 1,2, 1,2 and 2,3,*
1
Seqirus, 63 Poplar Road, Parkville 3052, Victoria, Australia
2
Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute of Infection and Immunity, 792 Elizabeth Street, Melbourne 3000, Victoria, Australia
3
WHO Collaborating Centre for Reference and Research on Influenza, at the Peter Doherty Institute for Infection and Immunity, 792 Elizabeth Street, Melbourne 3000, Victoria, Australia
*
Author to whom correspondence should be addressed.
Vaccines 2020, 8(2), 211; https://doi.org/10.3390/vaccines8020211
Received: 4 April 2020 / Revised: 1 May 2020 / Accepted: 6 May 2020 / Published: 7 May 2020
(This article belongs to the Special Issue Influenza Virus and Vaccine Development)
In 2009, a novel A(H1N1) influenza virus emerged with rapid human-to-human spread and caused the first pandemic of the 21st century. Although this pandemic was considered mild compared to the previous pandemics of the 20th century, there was still extensive disease and death. This virus replaced the previous A(H1N1) and continues to circulate today as a seasonal virus. It is well established that vaccines are the most effective method to alleviate the mortality and morbidity associated with influenza virus infections, but the 2009 A(H1N1) influenza pandemic, like all significant infectious disease outbreaks, presented its own unique set of problems with vaccine supply and demand. This manuscript describes the issues that confronted governments, international agencies and industries in developing a well-matched vaccine in 2009, and identifies the key improvements and remaining challenges facing the world as the next influenza pandemic inevitably approaches. View Full-Text
Keywords: influenza vaccine; pandemic; pandemic preparedness; influenza; A(H1N1)pdm09; seasonal influenza vaccine; pandemic influenza vaccine; pandemic vaccine influenza vaccine; pandemic; pandemic preparedness; influenza; A(H1N1)pdm09; seasonal influenza vaccine; pandemic influenza vaccine; pandemic vaccine
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Rockman, S.; Laurie, K.; Barr, I. Pandemic Influenza Vaccines: What did We Learn from the 2009 Pandemic and are We Better Prepared Now? Vaccines 2020, 8, 211.

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