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Vaccines 2015, 3(2), 467-489;

The Promise of Preventive Cancer Vaccines

Department of Experimental Diagnostic and Specialty Medicine (DIMES), University of Bologna, Viale Filopanti 22, Bologna 40126, Italy
Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Via Nizza 52, Torino 10126, Italy
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Mary Lenora (Nora) Disis
Received: 17 April 2015 / Revised: 4 June 2015 / Accepted: 8 June 2015 / Published: 17 June 2015
(This article belongs to the Special Issue Cancer Vaccines)
Full-Text   |   PDF [420 KB, uploaded 17 June 2015]   |  


Years of unsuccessful attempts at fighting established tumors with vaccines have taught us all that they are only able to truly impact patient survival when used in a preventive setting, as would normally be the case for traditional vaccines against infectious diseases. While true primary cancer prevention is still but a long-term goal, secondary and tertiary prevention are already in the clinic and providing encouraging results. A combination of immunopreventive cancer strategies and recently approved checkpoint inhibitors is a further promise of forthcoming successful cancer disease control, but prevention will require a considerable reduction of currently reported toxicities. These considerations summed with the increased understanding of tumor antigens allow space for an optimistic view of the future. View Full-Text
Keywords: cancer vaccines; cancer immunoprevention; cancer immunotherapy; Her2; immune checkpoint inhibitors cancer vaccines; cancer immunoprevention; cancer immunotherapy; Her2; immune checkpoint inhibitors

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Lollini, P.-L.; Cavallo, F.; Nanni, P.; Quaglino, E. The Promise of Preventive Cancer Vaccines. Vaccines 2015, 3, 467-489.

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