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Review

Nox, Reactive Oxygen Species and Regulation of Vascular Cell Fate

1
Vascular Biology & Therapeutics, School of Biotechnology, Dublin City University, D09NR58 Dublin, Ireland
2
Department of Surgery (Research), University of Rochester Medical Centre, Rochester, NY 14620, USA
*
Author to whom correspondence should be addressed.
Antioxidants 2017, 6(4), 90; https://doi.org/10.3390/antiox6040090
Received: 2 October 2017 / Revised: 21 October 2017 / Accepted: 7 November 2017 / Published: 14 November 2017
(This article belongs to the Special Issue ROS Derived from NADPH Oxidase (NOX) in Angiogenesis)
The generation of reactive oxygen species (ROS) and an imbalance of antioxidant defence mechanisms can result in oxidative stress. Several pro-atherogenic stimuli that promote intimal-medial thickening (IMT) and early arteriosclerotic disease progression share oxidative stress as a common regulatory pathway dictating vascular cell fate. The major source of ROS generated within the vascular system is the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase family of enzymes (Nox), of which seven members have been characterized. The Nox family are critical determinants of the redox state within the vessel wall that dictate, in part the pathophysiology of several vascular phenotypes. This review highlights the putative role of ROS in controlling vascular fate by promoting endothelial dysfunction, altering vascular smooth muscle phenotype and dictating resident vascular stem cell fate, all of which contribute to intimal medial thickening and vascular disease progression. View Full-Text
Keywords: Nox; ROS; vascular smooth muscle; endothelial; stem cells; adventitial cells; arteriosclerotic disease; intimal-medial thickening Nox; ROS; vascular smooth muscle; endothelial; stem cells; adventitial cells; arteriosclerotic disease; intimal-medial thickening
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MDPI and ACS Style

Burtenshaw, D.; Hakimjavadi, R.; Redmond, E.M.; Cahill, P.A. Nox, Reactive Oxygen Species and Regulation of Vascular Cell Fate. Antioxidants 2017, 6, 90. https://doi.org/10.3390/antiox6040090

AMA Style

Burtenshaw D, Hakimjavadi R, Redmond EM, Cahill PA. Nox, Reactive Oxygen Species and Regulation of Vascular Cell Fate. Antioxidants. 2017; 6(4):90. https://doi.org/10.3390/antiox6040090

Chicago/Turabian Style

Burtenshaw, Denise, Roya Hakimjavadi, Eileen M. Redmond, and Paul A. Cahill. 2017. "Nox, Reactive Oxygen Species and Regulation of Vascular Cell Fate" Antioxidants 6, no. 4: 90. https://doi.org/10.3390/antiox6040090

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