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Antioxidants 2015, 4(3), 577-590;

Periodontal Disease-Induced Atherosclerosis and Oxidative Stress

Department of Microbiology and Immunology, Nihon University School of Dentistry at Matsudo, Chiba 271-8587, Japan
Stomatology Hospital, Tongji University, Shanghai 200072, China
Department of Periodontology, Peking University School and Hospital of Stomatology, 22 Zhongguancun Avenue South, Haidian District, Beijing 100081, China
Department of Oral and Maxillofacial Surgery, School of Medicine, Tokyo Women's Medical University, Tokyo 162-8666, Japan
Author to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Received: 9 July 2015 / Revised: 11 August 2015 / Accepted: 18 August 2015 / Published: 2 September 2015
(This article belongs to the Special Issue Antioxidants and Periodontal Diseases)
Full-Text   |   PDF [426 KB, uploaded 2 September 2015]


Periodontal disease is a highly prevalent disorder affecting up to 80% of the global population. Recent epidemiological studies have shown an association between periodontal disease and cardiovascular disease, as oxidative stress plays an important role in chronic inflammatory diseases such as periodontal disease and cardiovascular disease. In this review, we focus on the mechanisms by which periodontopathic bacteria cause chronic inflammation through the enhancement of oxidative stress and accelerate cardiovascular disease. Furthermore, we comment on the antioxidative activity of catechin in atherosclerosis accelerated by periodontitis. View Full-Text
Keywords: inflammation; oxidative stress; systemic chronic disease; atherosclerosis; periodontal disease inflammation; oxidative stress; systemic chronic disease; atherosclerosis; periodontal disease
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Kurita-Ochiai, T.; Jia, R.; Cai, Y.; Yamaguchi, Y.; Yamamoto, M. Periodontal Disease-Induced Atherosclerosis and Oxidative Stress. Antioxidants 2015, 4, 577-590.

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