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Article

Antioxidant and Antiaging Properties of a Novel Synergistic Nutraceutical Complex: Readouts from an In Cellulo Study and an In Vivo Prospective, Randomized Trial

1
Institute of Chemical Biology, National Hellenic Research Foundation, 11635 Athens, Greece
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Faculty of Medicine, School of Health Sciences, University of Thessaly, 41334 Larisa, Greece
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TheraCell Advanced Biotechnologies, 14564 Kifisia, Greece
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Department of Physical Education and Sport Science, Aristotle University, 57001 Thessaloniki, Greece
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Orthobiotiki Clinic, 15125 Marousi, Greece
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Metropolitan Hospital, 18547 Athens, Greece
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Hellenic Pasteur Institute, 11521 Athens, Greece
*
Author to whom correspondence should be addressed.
Academic Editors: Stanley Omaye, Edward E. Schmidt, Hozumi Motohashi and Anna Kipp
Antioxidants 2022, 11(3), 468; https://doi.org/10.3390/antiox11030468
Received: 31 January 2022 / Revised: 22 February 2022 / Accepted: 25 February 2022 / Published: 26 February 2022
(This article belongs to the Topic Cellular Redox Homeostasis)
Aging is a dynamic procedure that is developed in multiple layers and characterized by distinct hallmarks. The use of biomarkers that target different hallmarks of aging is substantial in predicting adverse outcomes during the aging process, implementing specifically designed antiaging interventions and monitoring responses to these interventions. The present study aimed to develop a novel composition of plant extracts, comprising identified active ingredients that synergistically target different hallmarks of aging in cellulo and in vivo. The selected single extracts and the developed composition were tested through a powerful set of biomarkers that we have previously identified and studied. The composition of selected extracts simultaneously increased cellular lifespan, reduced the cellular oxidative load and enhanced antioxidant defense mechanisms by increasing proteasome activity and content. In addition, the combination prevented telomere attrition and preserved optimum DNA methylation levels. Remarkably, biomarker profiling of healthy volunteers who received the identified combination in the form of a nutritional supplement within the frame of a prospective, randomized, controlled 3-month trial revealed an unprecedented antioxidant capacity in humans. In conclusion, our results support the notion that interventions with specifically designed combinations of natural compounds targeting multiple hallmarks of aging represent an effective way to improve healthspan and well-being. View Full-Text
Keywords: nutraceuticals; dietary supplements; antioxidant defense; proteostasis; well-being nutraceuticals; dietary supplements; antioxidant defense; proteostasis; well-being
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MDPI and ACS Style

Athanasopoulou, S.; Kapetanou, M.; Magouritsas, M.G.; Mougkolia, N.; Taouxidou, P.; Papacharalambous, M.; Sakellaridis, F.; Gonos, E. Antioxidant and Antiaging Properties of a Novel Synergistic Nutraceutical Complex: Readouts from an In Cellulo Study and an In Vivo Prospective, Randomized Trial. Antioxidants 2022, 11, 468. https://doi.org/10.3390/antiox11030468

AMA Style

Athanasopoulou S, Kapetanou M, Magouritsas MG, Mougkolia N, Taouxidou P, Papacharalambous M, Sakellaridis F, Gonos E. Antioxidant and Antiaging Properties of a Novel Synergistic Nutraceutical Complex: Readouts from an In Cellulo Study and an In Vivo Prospective, Randomized Trial. Antioxidants. 2022; 11(3):468. https://doi.org/10.3390/antiox11030468

Chicago/Turabian Style

Athanasopoulou, Sophia, Marianna Kapetanou, Michel G. Magouritsas, Nikoletta Mougkolia, Polykseni Taouxidou, Michael Papacharalambous, Fotios Sakellaridis, and Efstathios Gonos. 2022. "Antioxidant and Antiaging Properties of a Novel Synergistic Nutraceutical Complex: Readouts from an In Cellulo Study and an In Vivo Prospective, Randomized Trial" Antioxidants 11, no. 3: 468. https://doi.org/10.3390/antiox11030468

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