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Article

Relationship between Vitamin C Deficiency and Cognitive Impairment in Older Hospitalised Patients: A Cross-Sectional Study

1
College of Medicine & Public Health, Flinders University, Adelaide 5042, Australia
2
Department of General Medicine, Division of Medicine, Cardiac & Critical Care, Flinders Medical Centre, Adelaide 5042, Australia
3
Department of Geriatrics & Rehabilitation, Flinders Medical Centre, Adelaide 5042, Australia
4
Department of Clinical Epidemiology, Flinders Medical Centre, Adelaide 5042, Australia
5
Discipline of Medicine, The University of Adelaide, Adelaide 5005, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Adrianne Bendich
Antioxidants 2022, 11(3), 463; https://doi.org/10.3390/antiox11030463
Received: 4 February 2022 / Revised: 22 February 2022 / Accepted: 24 February 2022 / Published: 26 February 2022
Vitamin C is a powerful antioxidant and facilitates neurotransmission. This study explored association between vitamin C deficiency and cognitive impairment in older hospitalised patients. This prospective study recruited 160 patients ≥ 75 years admitted under a Geriatric Unit in Australia. Cognitive assessment was performed by use of the Mini-Mental-State-Examination (MMSE) and patients with MMSE scores <24 were classified as cognitively-impaired. Fasting plasma vitamin C levels were determined using high-performance-liquid-chromatography. Patients were classified as vitamin C deficient if their levels were below 11 micromol/L. Logistic regression analysis was used to determine whether vitamin C deficiency was associated with cognitive impairment after adjustment for various covariates. The mean (SD) age was 84.4 (6.4) years and 60% were females. A total of 91 (56.9%) were found to have cognitive impairment, while 42 (26.3%) were found to be vitamin C deficient. The mean (SD) MMSE scores were significantly lower among patients who were vitamin C deficient (24.9 (3.3) vs. 23.6 (3.4), p-value = 0.03). Logistic regression analysis suggested that vitamin C deficiency was 2.9-fold more likely to be associated with cognitive impairment after adjustment for covariates (aOR 2.93, 95% CI 1.05–8.19, p-value = 0.031). Vitamin C deficiency is common and is associated with cognitive impairment in older hospitalised patients. View Full-Text
Keywords: vitamin C deficiency; cognitive impairment; geriatric patients; older hospitalised patients; clock drawing test; mini mental state examination vitamin C deficiency; cognitive impairment; geriatric patients; older hospitalised patients; clock drawing test; mini mental state examination
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MDPI and ACS Style

Sharma, Y.; Popescu, A.; Horwood, C.; Hakendorf, P.; Thompson, C. Relationship between Vitamin C Deficiency and Cognitive Impairment in Older Hospitalised Patients: A Cross-Sectional Study. Antioxidants 2022, 11, 463. https://doi.org/10.3390/antiox11030463

AMA Style

Sharma Y, Popescu A, Horwood C, Hakendorf P, Thompson C. Relationship between Vitamin C Deficiency and Cognitive Impairment in Older Hospitalised Patients: A Cross-Sectional Study. Antioxidants. 2022; 11(3):463. https://doi.org/10.3390/antiox11030463

Chicago/Turabian Style

Sharma, Yogesh, Alexandra Popescu, Chris Horwood, Paul Hakendorf, and Campbell Thompson. 2022. "Relationship between Vitamin C Deficiency and Cognitive Impairment in Older Hospitalised Patients: A Cross-Sectional Study" Antioxidants 11, no. 3: 463. https://doi.org/10.3390/antiox11030463

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