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Brief Report

Melatonin Ameliorates Autophagy Impairment in a Metabolic Syndrome Model

1
Institute of Neurosciences of Castilla y León-INCYL, Institute of Biomedical Research of Salamanca-IBSAL, Cell Biology and Pathology, University of Salamanca, 37007 Salamanca, Spain
2
Centre for Tumour Biology, Barts Cancer Institute-Queen Mary, University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK
3
Departamento de Morfología y Biología Celular, Área de Biología Celular, Facultad de Medicina, Universidad de Oviedo, Julián Clavería s/n, 33006 Oviedo, Spain
4
Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Av. del Hospital Universitario, s/n, 33011 Oviedo, Spain
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Servicio de Microbiología, Hospital Universitario Central de Asturias, Celestino Villamil s/n, 33006 Oviedo, Spain
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Institute of Biomedical Research of Salamanca, University Hospital of Salamanca, 37007 Salamanca, Spain
7
Institute of Functional Biology and Genomics, University of Salamanca, CSIC, 37007 Salamanca, Spain
8
Centro de Investigación Biomédica en Red Sobre Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, 28029 Madrid, Spain
*
Authors to whom correspondence should be addressed.
Academic Editors: Angeles Aroca and Cecilia Gotor
Antioxidants 2021, 10(5), 796; https://doi.org/10.3390/antiox10050796
Received: 22 April 2021 / Revised: 13 May 2021 / Accepted: 15 May 2021 / Published: 18 May 2021
(This article belongs to the Special Issue Regulation of Autophagy under Stress)
Metabolic syndrome is a global health problem in adults and its prevalence among children and adolescents is rising. It is strongly linked to a lifestyle with high-caloric food, which causes obesity and lipid metabolism anomalies. Molecular damage due to excessive oxidative stress plays a major role during the development of metabolic syndrome complications. Among the different hormones, melatonin presents strong antioxidant properties, and it is used to treat metabolic diseases. However, there is not a consensus about its use as a metabolic syndrome treatment. The aim of this study was to identify melatonin effects in a metabolic syndrome model. Golden hamsters were fed with 60% fructose-enriched food to induce metabolic syndrome and were compared to hamsters fed with regular chow diet. Both groups were also treated with melatonin. Fructose-fed hamsters showed altered blood lipid levels (increased cholesterol and LDL) and phenotypes restored with the melatonin treatment. The Harderian gland (HG), which is an ideal model to study autophagy modulation through oxidative stress, was the organ that was most affected by a fructose diet. Redox balance was altered in fructose-fed HG, inducing autophagic activation. However, since LC3-II was not increased, the impairment must be in the last steps of autophagy. Lipophagy HG markers were also disturbed, contributing to the dyslipidemia. Melatonin treatment improved possible oxidative homeostasis through autophagic induction. All these results point to melatonin as a possible treatment of the metabolic syndrome. View Full-Text
Keywords: melatonin; metabolic syndrome; autophagy; lipophagy; Harderian gland melatonin; metabolic syndrome; autophagy; lipophagy; Harderian gland
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MDPI and ACS Style

Santos-Ledo, A.; Luxán-Delgado, B.d.; Caballero, B.; Potes, Y.; Rodríguez-González, S.; Boga, J.A.; Coto-Montes, A.; García-Macia, M. Melatonin Ameliorates Autophagy Impairment in a Metabolic Syndrome Model. Antioxidants 2021, 10, 796. https://doi.org/10.3390/antiox10050796

AMA Style

Santos-Ledo A, Luxán-Delgado Bd, Caballero B, Potes Y, Rodríguez-González S, Boga JA, Coto-Montes A, García-Macia M. Melatonin Ameliorates Autophagy Impairment in a Metabolic Syndrome Model. Antioxidants. 2021; 10(5):796. https://doi.org/10.3390/antiox10050796

Chicago/Turabian Style

Santos-Ledo, Adrián, Beatriz d. Luxán-Delgado, Beatriz Caballero, Yaiza Potes, Susana Rodríguez-González, José A. Boga, Ana Coto-Montes, and Marina García-Macia. 2021. "Melatonin Ameliorates Autophagy Impairment in a Metabolic Syndrome Model" Antioxidants 10, no. 5: 796. https://doi.org/10.3390/antiox10050796

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