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Potential Application of Optogenetic Stimulation in the Treatment of Pain and Migraine Headache: A Perspective from Animal Studies

1
Department of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, Texas 75246, USA
2
Department of Physiology, Zhengzhou University School of Medicine, Zhengzhou 450001, China
3
School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, China
4
Center for Craniofacial Research and Diagnosis, Texas A&M University College of Dentistry, 3302 Gaston Avenue, Dallas, Texas 75246, USA
*
Author to whom correspondence should be addressed.
Brain Sci. 2019, 9(2), 26; https://doi.org/10.3390/brainsci9020026
Received: 15 December 2018 / Revised: 22 January 2019 / Accepted: 22 January 2019 / Published: 29 January 2019
(This article belongs to the Special Issue Mechanisms Underlying Alleviation of Pain)
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Abstract

Optogenetic manipulation is uniquely useful in unraveling the functional organization of neuronal circuits in the central nervous system by enabling reversible gain- or loss-of-function of discrete populations of neurons within restricted brain regions. This state-of-the-art technology can produce circuit-specific neuromodulation by overexpressing light-sensitive proteins (opsins) in particular cell types of interest. Here, we discuss the principle of optogenetic manipulation and its application in pain research using animal models, and we also discuss how to potentially use optogenetic stimulation in the treatment of migraine headache in the future. View Full-Text
Keywords: migraine-like pain; optogenetics; neuronal activity modulation; neuronal excitation; neuronal inhibition migraine-like pain; optogenetics; neuronal activity modulation; neuronal excitation; neuronal inhibition
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Liu, S.; Tang, Y.; Xing, Y.; Kramer, P.; Bellinger, L.; Tao, F. Potential Application of Optogenetic Stimulation in the Treatment of Pain and Migraine Headache: A Perspective from Animal Studies. Brain Sci. 2019, 9, 26.

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