Next Article in Journal
Development of the Morphology and the Band Gap Energy of Co–Si Nanofibers by Inserting Zirconium and Titanium with Dual Anions Intercalation Process
Previous Article in Journal
Editorial for Special Issue: Fishery Acoustics, Applied Sciences, and Practical Applications
Previous Article in Special Issue
Reconstruction of the Microstructure of Cyanate Ester Resin by Using Prepared Cyanate Ester Resin Nanoparticles and Analysis of the Curing Kinetics Using the Avrami Equation of Phase Change
Open AccessArticle

Polyisobutylene-Based Thermoplastic Elastomers for Manufacturing Polymeric Heart Valve Leaflets: In Vitro and In Vivo Results

1
Research Institute for Complex Issues of Cardiovascular Diseases, 650002 Kemerovo, Russia
2
Research Institute for Physical Chemical Problems of the Belarusian State University, 220030 Minsk, Belarus
3
Faculty of Chemistry, Belarusian State University, 220030 Minsk, Belarus
4
Institute of Regenerative Medicine, Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 119991 Moscow, Russia
5
OOO Angiolain, 630090 Novosibirsk, Russia
*
Author to whom correspondence should be addressed.
Appl. Sci. 2019, 9(22), 4773; https://doi.org/10.3390/app9224773
Received: 30 September 2019 / Revised: 26 October 2019 / Accepted: 5 November 2019 / Published: 8 November 2019
(This article belongs to the Special Issue Phase Transitions in Polymer and Polymer-Based (Nano)Composites)
Superior polymers represent a promising alternative to mechanical and biological materials commonly used for manufacturing artificial heart valves. The study is aimed at assessing poly(styrene-block-isobutylene-block-styrene) (SIBS) properties and comparing them with polytetrafluoroethylene (Gore-texTM, a reference sample). Surface topography of both materials was evaluated with scanning electron microscopy and atomic force microscopy. The mechanical properties were measured under uniaxial tension. The water contact angle was estimated to evaluate hydrophilicity/hydrophobicity of the study samples. Materials’ hemocompatibility was evaluated using cell lines (Ea.hy 926), donor blood, and in vivo. SIBS possess a regular surface relief. It is hydrophobic and has lower strength as compared to Gore-texTM (3.51 MPa vs. 13.2/23.8 MPa). SIBS and Gore-texTM have similar hemocompatibility (hemolysis, adhesion, and platelet aggregation). The subcutaneous rat implantation reports that SIBS has a lower tendency towards calcification (0.39 mg/g) compared with Gore-texTM (1.29 mg/g). SIBS is a highly hemocompatible material with a promising potential for manufacturing heart valve leaflets, but its mechanical properties require further improvements. The possible options include the reinforcement with nanofillers and introductions of new chains in its structure. View Full-Text
Keywords: polymeric heart valve leaflets; ABA block copolymers of isobutylene and styrene; biostability; hemocompatibility; physical and mechanical properties polymeric heart valve leaflets; ABA block copolymers of isobutylene and styrene; biostability; hemocompatibility; physical and mechanical properties
Show Figures

Graphical abstract

MDPI and ACS Style

Ovcharenko, E.; Rezvova, M.; Nikishau, P.; Kostjuk, S.; Glushkova, T.; Antonova, L.; Trebushat, D.; Akentieva, T.; Shishkova, D.; Krivikina, E.; Klyshnikov, K.; Kudryavtseva, Y.; Barbarash, L. Polyisobutylene-Based Thermoplastic Elastomers for Manufacturing Polymeric Heart Valve Leaflets: In Vitro and In Vivo Results. Appl. Sci. 2019, 9, 4773.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop