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Open AccessArticle

A Versatile Setup for Time-Resolved Functional Near Infrared Spectroscopy Based on Fast-Gated Single-Photon Avalanche Diode and on Four-Wave Mixing Laser

1
Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, I-20133 Milano, Italy
2
Consiglio Nazionale delle Ricerche, Istituto di Fotonica e Nanotecnologie, Piazza Leonardo da Vinci 32, 20133 Milano-I, Italy
*
Author to whom correspondence should be addressed.
Appl. Sci. 2019, 9(11), 2366; https://doi.org/10.3390/app9112366
Received: 15 April 2019 / Revised: 1 June 2019 / Accepted: 4 June 2019 / Published: 10 June 2019
(This article belongs to the Special Issue New Horizons in Time-Domain Diffuse Optical Spectroscopy and Imaging)
In this paper, a time-domain fast gated near-infrared spectroscopy system is presented. The system is composed of a fiber-based laser providing two pulsed sources and two fast gated detectors. The system is characterized on phantoms and was tested in vivo, showing how the gating approach can improve the contrast and contrast-to-noise-ratio for detection of absorption perturbation inside a diffusive medium, regardless of source-detector separation. View Full-Text
Keywords: time-domain NIRS; null source-detector separation; brain; diffuse optics time-domain NIRS; null source-detector separation; brain; diffuse optics
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MDPI and ACS Style

Di Sieno, L.; Dalla Mora, A.; Torricelli, A.; Spinelli, L.; Re, R.; Pifferi, A.; Contini, D. A Versatile Setup for Time-Resolved Functional Near Infrared Spectroscopy Based on Fast-Gated Single-Photon Avalanche Diode and on Four-Wave Mixing Laser. Appl. Sci. 2019, 9, 2366.

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