- Article
Radiosynthesis and in Vivo Evaluation of Two PET Radioligands for Imaging α-Synuclein
- Xiang Zhang,
- Hongjun Jin,
- Prashanth K. Padakanti,
- Junfeng Li,
- Hao Yang,
- Jinda Fan,
- Robert H. Mach,
- Paul Kotzbauer and
- Zhude Tu
Two α-synuclein ligands, 3-methoxy-7-nitro-10H-phenothiazine (2a, Ki = 32.1 ± 1.3 nM) and 3-(2-fluoroethoxy)-7-nitro-10H-phenothiazine (2b, Ki = 49.0 ± 4.9 nM), were radiolabeled as potential PET imaging agents by respectively introducing 11C and 1...

