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Applied Sciences
Volume 15
Issue 13
10.3390/app15137357
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Review

Bioactivity of Secondary Metabolites and Extracts from the Leontopodium R.Br. ex Cass. Taxa with Targeted Medicinal Applications

by
Elena-Monica Mitoi
1,
Alexandra-Gabriela Ciocan
1,
Irina Holobiuc
1,
Gina Cogălniceanu
1,
Carmen Maximilian
1,* and
Georgiana Duta-Cornescu
2
1
Department of Developmental Biology, Institute of Biology Bucharest of Romanian Academy, 296 Splaiul Independenței Street, 060031 Bucharest, Romania
2
Genetic Department, Faculty of Biology, University of Bucharest, Intrarea Portocalelor 1-3, Sector 6, 060101 Bucharest, Romania
*
Author to whom correspondence should be addressed.
Appl. Sci. 2025, 15(13), 7357; https://doi.org/10.3390/app15137357 (registering DOI)
Submission received: 26 May 2025 / Revised: 23 June 2025 / Accepted: 27 June 2025 / Published: 30 June 2025
(This article belongs to the Special Issue Biological Activities of Medicinal Plants and Their Potential Applications)
Versions Notes

Abstract

The Leontopodium R.Br. ex Cass. taxa have been extensively phytochemically researched for their beneficial properties by the pharmaceuticals industry. These species have been used as remedies since ancient times, and their usage in traditional medicine has been a source of inspiration for current research. As a result, a comprehensive review study concerning the bioactivities of secondary metabolites belonging to Leontopodium species would be of great interest. Our research shows that the majority of studies addressed the anti-inflammatory activity, and the most studied compound was leoligin, a lignan with cardioprotective properties. The diverse range of bioactivities were intricately linked to the abundance of secondary metabolites, which conferred effective antimicrobial activity, antioxidant properties, the anti-neurodegenerative potential due to improvements in cholinergic transmission, the anti-tumour effects on various cancer cell lines, particularly breast and lung cancer, and the hypoglycaemic and hepatoprotective properties. All these important bioactivities also recommend Leontopodium taxa as a valuable source for the discovery of new drugs.
Keywords: Leontopodium; secondary metabolites; bioactivity; anti-inflammatory; antimicrobial; anti-neurodegenerative; anti-tumoral; antioxidant Leontopodium; secondary metabolites; bioactivity; anti-inflammatory; antimicrobial; anti-neurodegenerative; anti-tumoral; antioxidant

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MDPI and ACS Style

Mitoi, E.-M.; Ciocan, A.-G.; Holobiuc, I.; Cogălniceanu, G.; Maximilian, C.; Duta-Cornescu, G. Bioactivity of Secondary Metabolites and Extracts from the Leontopodium R.Br. ex Cass. Taxa with Targeted Medicinal Applications. Appl. Sci. 2025, 15, 7357. https://doi.org/10.3390/app15137357

AMA Style

Mitoi E-M, Ciocan A-G, Holobiuc I, Cogălniceanu G, Maximilian C, Duta-Cornescu G. Bioactivity of Secondary Metabolites and Extracts from the Leontopodium R.Br. ex Cass. Taxa with Targeted Medicinal Applications. Applied Sciences. 2025; 15(13):7357. https://doi.org/10.3390/app15137357

Chicago/Turabian Style

Mitoi, Elena-Monica, Alexandra-Gabriela Ciocan, Irina Holobiuc, Gina Cogălniceanu, Carmen Maximilian, and Georgiana Duta-Cornescu. 2025. "Bioactivity of Secondary Metabolites and Extracts from the Leontopodium R.Br. ex Cass. Taxa with Targeted Medicinal Applications" Applied Sciences 15, no. 13: 7357. https://doi.org/10.3390/app15137357

APA Style

Mitoi, E.-M., Ciocan, A.-G., Holobiuc, I., Cogălniceanu, G., Maximilian, C., & Duta-Cornescu, G. (2025). Bioactivity of Secondary Metabolites and Extracts from the Leontopodium R.Br. ex Cass. Taxa with Targeted Medicinal Applications. Applied Sciences, 15(13), 7357. https://doi.org/10.3390/app15137357

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