Usage of Guided Bone Regeneration in the Case of Lateral Periodontal Cyst in the Maxilla with Buccal Cortical Expansion

Round 1

Reviewer 1 Report

1. “Both premolars remain vital to cold stimulus” cold test is usually used to evaluate the sensibility of pulp. It will be more appropriate to write both premolars response well to cold stimulus.

2. Did the authors sent the cystic lesion of histo-pathological examination to rule out other differential diagnosis?

3. The authors used lots of abbreviation in the text, please provide the full name followed by abbreviation.

4. Perhaps the authors could try to compare the present case with other published cases since the present case is more extensive involving cortical bone plate.

5. The conclusion is too long, please summarize and offer solid evidence or highlights that the authors would like to offer to the readers.

Author Response

thank you for the review, all issues had been covered

Author Response File: Author Response.docx

Reviewer 2 Report

This article is well introduced but is a typical case report that could rather be of interest for clinicians than researchers. In my opinion, this paper does not match a revue such as Applied Sciences. The references are not really evidence-based written.

Author Response

thank you for the review, all issues had been covered

Author Response File: Author Response.docx

Reviewer 3 Report

Line 119 : Explanation should be given concerning the decision to perform the endodontic treatment of the vital and healthy first premolar (see discussion line 257)

Line 123 : minutes and not minuters !

Line 124 & Line 160 : Promotion of Nimesil (Nimesulide) cannot be accepted following the bulletin below

International society of drug bulletins, 2007 (Source : Therapeutics Initiative, UBC):

« Nimesulide has never been approved for use in countries like USA, UK, Canada, Australia New Zealand, Japan and other countries in view of concerns over its safety profile.

In 2002, Finland and Spain withdrew nimesulide from the market following reports of serious liver damage. Cases including 2 deaths had also been reported in France at the time. Ireland and Singapore decided to withdraw nimesulide from the market in 2007.

The European Medicines Agency has confirmed the hepatic risks associated with nimesulide in 2007, but merely limited the duration of treatment, leaving patients exposed to an unjustifiable fatal risk. These half-hearted measures are all the more unacceptable since numerous other available NSAIDs are just as effective and less dangerous. »

Fig 5 :

-A clinical view of the defect would have been greatly appreciated

-The different steps of bone filling and collagen membrane covering are missing

-The clinical view is a poor quality picture

Line 175 : Individually and not indyvidually

Line 218 : Withy ?

Lines 233-244 : Not well-turned phrase

Line 261 & 297: Healing and not heling

Line 264 : Or and not od

Bibliography : see lines 338 ; 343 ; 353

Discussion: It would have been particularly interesting to discuss

-the indication of the membrane and its time of resorption

-the interest of the iPRF 

-the indication of the cyst filling with biomaterial instead of a spontaneous healing

Author Response

thank you for the review, all issues had been covered

Author Response File: Author Response.docx

Reviewer 4 Report

Author

Thank you for your work. The present report evaluated the application of GBR on Lateral Periodontal Cyst LPC following enucleation. Overall, a good report on interesting topic, however, please see the following suggestions to improve your work.

Introduction 

Its an unusual odontogenic cyst of benign potential, with occurrence estimation of 0,4-1%. This sentence needs references.

The abbreviation ex is not correct, pls revise. 

It should be described about how to differentiate between LPC and other possibilities. In addition, it should be clearly described about the radiographic examination as the treatment options are based on that.

Pls describe about iPRF and GBR.

Pls use “ . ” instead of “ , ” (0.1% CHX) in all text.

Case report presentation

It should be written about the patient chief complaints, symptoms then the examination etc, ….

- Chief Complaints, Medical and Dental History and current symptoms

- Examination (Clinical and Radiographic)

- Tx (Surgical procedure with follow up?)

Figure caption for figure 1 must be revised

Figures for Intraoral photographs should be combined (Fig 2, 5, 8 -11) 

Again, figures for CBCT should be combined (Before surgery and After surgery)

In addition, is it enough to confirm the diagnosis without any histology? Otherwise, it should be discussed?

Line 239 need refs.

Pls include the further study.

References

It must be thoroughly revised, pls follow the journal guidelines.

Remarks

If you feel that your paper could benefit from English language polishing, you may wish to consider having your paper professionally edited for English language?

Author Response

all questions, concerns and major issues had been added - thank you for a great review 

Author Response File: Author Response.docx

Reviewer 5 Report

Moderate English changes required

Author Response

thank you for the review, all issues had been covered

Author Response File: Author Response.docx

Round 2

Reviewer 2 Report

Thank the authors for improving the paper in a way that can be published in Applied Sciences

Reviewer 3 Report

The authors have corrected all the errors .

They have given a proper information concerning the risk to prescribe Nimesil, and the fact that this molecule is fewly or not prescribed in most western countries.

Unfortunately, no improvement can be provided for the iconography of the case ; this is a pity for a one case report.