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Microorganisms
Volume 9
Issue 4
10.3390/microorganisms9040871
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Article
Peer-Review Record

The Gut Microbiota Can Provide Viral Tolerance in the Honey Bee

Microorganisms 2021, 9(4), 871; https://doi.org/10.3390/microorganisms9040871
by Christopher Dosch †, Anja Manigk †, Tabea Streicher, Anja Tehel, Robert J. Paxton and Simon Tragust *
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Microorganisms 2021, 9(4), 871; https://doi.org/10.3390/microorganisms9040871
Submission received: 29 March 2021 / Revised: 14 April 2021 / Accepted: 16 April 2021 / Published: 17 April 2021
(This article belongs to the Special Issue Microorganisms in Pollinators: Interactions with Other Factors)

Round 1

Reviewer 1 Report

Dosch et al presented and interesting manuscript about the effect of the gut microbiota on viral tolerance in the honey bee. upon oral virus exposure, honey bee survival was significantly increased in bees with an experimentally established normal gut microbiota compared to control bees with a perturbed (dysbiotic) gut microbiota.  Viral loads were comparable in
bees with a normal gut microbiota and dysbiotic bees. The authors concluded that the gut microbiota have a crucial role for honey bee fitness upon viral infection.

In general the manuscript is well designed, nicely written, and easily flowed. This type of manuscript should be published.

Author Response

We thank the reviewer for this assessment of the manuscript and are glad that the manuscript elicited these compliments.

Reviewer 2 Report

The manuscript of Dosch and colleague highlighted the evidence for an important role of the gut microbiota for honey bee fitness against the DWV infection.

The research is well conducted and the results are clearly presented.

The authors hypothesised that environmental stressors (antibiotics in beekeeping or pesticides) altering the honey bee gut microbiota composition, due to their possible synergistically interaction with pathogens. In this contest, I think it is important to cite two work aimed to investigate the microbial profile changes considering the honey bee in-hive tasks and after the administration of products commonly used in beekeping. https://pubmed.ncbi.nlm.nih.gov/32517254/

https://www.tandfonline.com/doi/abs/10.1080/00218839.2020.1830259

 

 

Author Response

We thank the reviewer for pointing out these references to us and have added them in line 419-424 as references 60 and 61. Line 419-424 now reads: “The results of our study together with the existence of potential indirect links [57], e.g. the influence of pesticides on the honey bee gut microbiota [59] and the influence of beekeeping practices [60,61] with likely percolating effects on nutrition and disease, highlight the need for integrated research investigating a multitude of factors in order to better understand the epidemiology and impact of honey bee viruses on their hosts.”

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