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Open AccessCommunication
Microorganisms 2015, 3(4), 903-912;

Susceptibility of Select Agents to Predation by Predatory Bacteria

Department of Medicine and the Center for Emerging Pathogens, Rutgers, New Jersey Medical School, Newark, NJ 07101, USA
Department of Oral Biology, Rutgers School of Dental Medicine, Newark, NJ 07101, USA
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Andrew McDowell
Received: 30 September 2015 / Revised: 8 November 2015 / Accepted: 13 November 2015 / Published: 2 December 2015
Full-Text   |   PDF [408 KB, uploaded 2 December 2015]


Select Agents are microorganisms and toxins considered to be exploitable as biological weapons. Although infections by many Select Agents can be treated by conventional antibiotics, the risk of an emerging or engineered drug resistant strain is of great concern. One group of microorganisms that is showing potential to control drug resistant Gram-negative bacteria are the predatory bacteria from the genera Bdellovibrio spp. and Micavibrio spp. In this study, we have examined the ability of Bdellovibrio bacteriovorus (B. bacteriovorus) strain 109J, HD100 and Micavibrio aeruginosavorus (M. aeruginosavorus) ARL-13 to prey on a variety of Select Agents. Our findings demonstrate that B. bacteriovorus and M. aeruginosavorus are able to prey efficiently on Yersinia pestis and Burkholderia mallei. Modest predation was also measured in co-cultures of B. bacteriovorus and Francisella tularensis. However, neither of the predators showed predation when Burkholderia pseudomallei and Brucella melitensis were used as prey. View Full-Text
Keywords: predatory bacteria; Bdellovibrio; Micavibrio; Select Agents predatory bacteria; Bdellovibrio; Micavibrio; Select Agents
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Russo, R.; Chae, R.; Mukherjee, S.; Singleton, E.J.; Occi, J.L.; Kadouri, D.E.; Connell, N.D. Susceptibility of Select Agents to Predation by Predatory Bacteria. Microorganisms 2015, 3, 903-912.

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