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Comparative Characterization of G Protein α Subunits in Aspergillus fumigatus
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Heterotrimeric G-Protein Signalers and RGSs in Aspergillus fumigatus

1
School of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Korea
2
Department of Integrative Biology, Kyungpook National University, Daegu 41566, Korea
3
Department of Bacteriology, University of Wisconsin, Madison, WI 53706, USA
4
Department of Systems Biotechnology, Konkuk University, Seoul 05029, Korea
5
Department of Microbiology, Graduate School, Daejeon University, Daejeon 34520, Korea
*
Authors to whom correspondence should be addressed.
Pathogens 2020, 9(11), 902; https://doi.org/10.3390/pathogens9110902
Received: 25 September 2020 / Revised: 27 October 2020 / Accepted: 27 October 2020 / Published: 28 October 2020
(This article belongs to the Special Issue Signal Transduction in Pathogenic Fungi)
The heterotrimeric G-protein (G-protein) signaling pathway is one of the most important signaling pathways that transmit external signals into the inside of the cell, triggering appropriate biological responses. The external signals are sensed by various G-protein-coupled receptors (GPCRs) and transmitted into G-proteins consisting of the α, β, and γ subunits. Regulators of G-protein signaling (RGSs) are the key controllers of G-protein signaling pathways. GPCRs, G-proteins, and RGSs are the primary upstream components of the G-protein signaling pathway, and they are highly conserved in most filamentous fungi, playing diverse roles in biological processes. Recent studies characterized the G-protein signaling components in the opportunistic pathogenic fungus Aspergillus fumigatus. In this review, we have summarized the characteristics and functions of GPCRs, G-proteins, and RGSs, and their regulatory roles in governing fungal growth, asexual development, germination, stress tolerance, and virulence in A. fumigatus. View Full-Text
Keywords: Aspergillus fumigatus; regulators of G-protein signaling; virulence; G-protein; G-protein-coupled receptors Aspergillus fumigatus; regulators of G-protein signaling; virulence; G-protein; G-protein-coupled receptors
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Park, H.-S.; Kim, M.-J.; Yu, J.-H.; Shin, K.-S. Heterotrimeric G-Protein Signalers and RGSs in Aspergillus fumigatus. Pathogens 2020, 9, 902.

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