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Open AccessFeature PaperReview

The Cooperative Functions of the EBNA3 Proteins Are Central to EBV Persistence and Latency

Molecular Virology, Department of Medicine, Imperial College London, London W2 1PG, UK
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Pathogens 2018, 7(1), 31; https://doi.org/10.3390/pathogens7010031
Received: 30 January 2018 / Revised: 26 February 2018 / Accepted: 7 March 2018 / Published: 17 March 2018
(This article belongs to the Special Issue Emerging Topics in Epstein-Barr virus-Associated Diseases)
The Epstein–Barr nuclear antigen 3 (EBNA3) family of proteins, comprising EBNA3A, EBNA3B, and EBNA3C, play pivotal roles in the asymptomatic persistence and life-long latency of Epstein–Barr virus (EBV) in the worldwide human population. EBNA3-mediated transcriptional reprogramming of numerous host cell genes promotes in vitro B cell transformation and EBV persistence in vivo. Despite structural and sequence similarities, and evidence of substantial cooperative activity between the EBNA3 proteins, they perform quite different, often opposing functions. Both EBNA3A and EBNA3C are involved in the repression of important tumour suppressive pathways and are considered oncogenic. In contrast, EBNA3B exhibits tumour suppressive functions. This review focuses on how the EBNA3 proteins achieve the delicate balance required to support EBV persistence and latency, with emphasis on the contribution of the Allday laboratory to the field of EBNA3 biology. View Full-Text
Keywords: Epstein–Barr virus; EBNA3 proteins; epigenetic regulation; viral oncogenes; viral tumour suppressor; CDKI regulation Epstein–Barr virus; EBNA3 proteins; epigenetic regulation; viral oncogenes; viral tumour suppressor; CDKI regulation
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MDPI and ACS Style

Styles, C.T.; Paschos, K.; White, R.E.; Farrell, P.J. The Cooperative Functions of the EBNA3 Proteins Are Central to EBV Persistence and Latency. Pathogens 2018, 7, 31.

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