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Potential SARS-CoV-2 Immune Correlates of Protection in Infection and Vaccine Immunization

Vaccine Branch, Center of for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
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Author to whom correspondence should be addressed.
Academic Editor: Luis Martinez-Sobrido
Pathogens 2021, 10(2), 138; https://doi.org/10.3390/pathogens10020138
Received: 9 January 2021 / Revised: 26 January 2021 / Accepted: 27 January 2021 / Published: 30 January 2021
(This article belongs to the Special Issue Immune Responses to Emerging Viruses)
Both SARS-CoV-2 infections and vaccines induce robust immune responses. Current data suggested that high neutralizing antibody titers with sustained Th1 responses might correlate with protection against viral transmission and disease development and severity. In addition, genetic and innate immune factors, including higher levels of type I interferons, as well as the induction of trained immunity and local mucosal immunity also contribute to lower risk of infection and amelioration of disease severity. The identification of immune correlates of protection will facilitate the development of effective vaccines and therapeutics strategies. View Full-Text
Keywords: SARS-CoV-2; neutralizing antibody; Th1 responses; T-cell immunity; innate immunity; type I interferon; trained immunity; mucosal immunity SARS-CoV-2; neutralizing antibody; Th1 responses; T-cell immunity; innate immunity; type I interferon; trained immunity; mucosal immunity
MDPI and ACS Style

Sui, Y.; Bekele, Y.; Berzofsky, J.A. Potential SARS-CoV-2 Immune Correlates of Protection in Infection and Vaccine Immunization. Pathogens 2021, 10, 138. https://doi.org/10.3390/pathogens10020138

AMA Style

Sui Y, Bekele Y, Berzofsky JA. Potential SARS-CoV-2 Immune Correlates of Protection in Infection and Vaccine Immunization. Pathogens. 2021; 10(2):138. https://doi.org/10.3390/pathogens10020138

Chicago/Turabian Style

Sui, Yongjun, Yonas Bekele, and Jay A. Berzofsky. 2021. "Potential SARS-CoV-2 Immune Correlates of Protection in Infection and Vaccine Immunization" Pathogens 10, no. 2: 138. https://doi.org/10.3390/pathogens10020138

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