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Endogenous Intoxication and Saliva Lipid Peroxidation in Patients with Lung Cancer

KhimServis Limited Liability Company, 143026 Moscow, Russia
Chair of Chemical Technology and Biotechnology, Omsk State Technical University, 644050 Omsk, Russia
Chair of Oncology with Radiotherapy, Omsk State Medical Academy, 644099 Omsk, Russia
Strasbourg University Hospital, 67000 Strasbourg, France
Author to whom correspondence should be addressed.
Academic Editors: David Wong and Martin Weber
Diagnostics 2016, 6(4), 39;
Received: 8 August 2016 / Revised: 7 November 2016 / Accepted: 9 November 2016 / Published: 16 November 2016
(This article belongs to the Special Issue Oral Fluid-Based Molecular Diagnostics)
PDF [1432 KB, uploaded 16 November 2016]


This research was aimed at a search for regularities in changes to parameters of endogenous intoxication and saliva lipid peroxidation in patients with lung cancer, non-malignant lung diseases, and apparently healthy people. All patients went through saliva sampling at an amount of 1 mL. A concentration of malondialdehyde (MDA) was measured according to a reaction with thiobarbituric acid, and a level of middle molecules (MM) was measured with UV spectroscopy at 254 and 280 nm, while the content of lipid peroxidation products was measured according to a degree of heptane extract light absorption at wavelengths of 220, 232, 278, and 400 nm. It has been revealed that in the context of lung cancer, the level of diene conjugates decreases, increasing the level of triene conjugates, Schiff’s bases, and MM. As a tumor grows, there is a decrease in the level of lipid peroxidation primary products and an increase in endotoxemia phenomena. The process is more apparent when going from local to locally advanced disease states. The nature of the MDA change is nonlinearly associated with tumor progression. The findings might be used to optimize traditional aids of diagnostics, in disease state forecasting, in treatment monitoring, etc. View Full-Text
Keywords: saliva; lung cancer; lipid peroxidation; middle molecules; malondialdehyde saliva; lung cancer; lipid peroxidation; middle molecules; malondialdehyde

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Bel’skaya, L.V.; Kosenok, V.K.; Massard, G. Endogenous Intoxication and Saliva Lipid Peroxidation in Patients with Lung Cancer. Diagnostics 2016, 6, 39.

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