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Diagnostics, Volume 3, Issue 2

June 2013 - 8 articles

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Articles (8)

  • Review
  • Open Access
10 Citations
16,042 Views
24 Pages

Non-Invasive Screening Tools for Down’s Syndrome: A Review

  • Kelly A. Sillence,
  • Tracey E. Madgett,
  • Llinos A. Roberts,
  • Timothy G. Overton and
  • Neil D. Avent

Down’s syndrome (DS) is the most common genetic cause of developmental delay with an incidence of 1 in 800 live births, and is the predominant reason why women choose to undergo invasive prenatal diagnosis. However, as invasive tests are associated w...

  • Article
  • Open Access
9 Citations
8,739 Views
8 Pages

Overview of Five-Years of Experience Performing Non-Invasive Fetal Sex Assessment in Maternal Blood

  • Sara Perlado-Marina,
  • Ana Bustamante-Aragones,
  • Laura Horcajada,
  • Maria Jose Trujillo-Tiebas,
  • Isabel Lorda-Sanchez,
  • Marta Ruiz Ramos,
  • Javier Plaza and
  • Marta Rodriguez de Alba

Since the discovery of the presence of fetal DNA in maternal blood, non-invasive fetal sex determination has been the test most widely translated into clinical practice. To date there is no agreement between the different laboratories performing suc...

  • Article
  • Open Access
12 Citations
10,403 Views
10 Pages

Computed Tomography (CT) Perfusion in Abdominal Cancer: Technical Aspects

  • Martin Lundsgaard Hansen,
  • Rikke Norling,
  • Carsten Lauridsen,
  • Eva Fallentin,
  • Lene Bæksgaard,
  • Klaus Fuglsang Kofoed,
  • Lars Bo Svendsen and
  • Michael Bachmann Nielsen

Computed Tomography (CT) Perfusion is an evolving method to visualize perfusion in organs and tissue. With the introduction of multidetector CT scanners, it is now possible to cover up to 16 cm in one rotation, and thereby making it possible to scan...

  • Article
  • Open Access
12 Citations
8,694 Views
12 Pages

Quantification of Right and Left Ventricular Function in Cardiac MR Imaging: Comparison of Semiautomatic and Manual Segmentation Algorithms

  • Miguel Souto,
  • Lambert Raul Masip,
  • Miguel Couto,
  • Jorge Juan Suárez-Cuenca,
  • Amparo Martínez,
  • Pablo G. Tahoces,
  • Jose Martin Carreira and
  • Pierre Croisille

The purpose of this study was to evaluate the performance of a semiautomatic segmentation method for the anatomical and functional assessment of both ventricles from cardiac cine magnetic resonance (MR) examinations, reducing user interaction to a “m...

  • Article
  • Open Access
29 Citations
14,973 Views
17 Pages

A Rapid, Multiplexed, High-Throughput Flow-Through Membrane Immunoassay: A Convenient Alternative to ELISA

  • Sujatha Ramachandran,
  • Mitra Singhal,
  • Katherine G. McKenzie,
  • Jennifer L. Osborn,
  • Amit Arjyal,
  • Sabina Dongol,
  • Stephen G. Baker,
  • Buddha Basnyat,
  • Jeremy Farrar and
  • Christiane Dolecek
  • + 3 authors

This paper describes a rapid, high-throughput flow-through membrane immunoassay (FMIA) platform. A nitrocellulose membrane was spotted in an array format with multiple capture and control reagents for each sample detection area, and assay steps were...

  • Article
  • Open Access
9 Citations
8,915 Views
10 Pages

Diagnosis of Upper and Lower Respiratory Tract Bacterial Infections with the Use of Multiplex PCR Assays

  • Athanasia Xirogianni,
  • Maria Tsolia,
  • Aliki Voyiatzi,
  • Maria Sioumala,
  • Antonia Makri,
  • Athina Argyropoulou,
  • Olga Paniara,
  • Panayotis Markoulatos,
  • Jenny Kourea-Kremastinou and
  • Georgina Tzanakaki

26 March 2013

The investigation of respiratory infections by molecular techniques provides important information about the epidemiology of respiratory disease, especially during the post-vaccination era. The objective of the present study was the detection of b...

  • Review
  • Open Access
12 Citations
6,734 Views
12 Pages

Can Coronary Artery Involvement in Kawasaki Disease be Predicted?

  • Sunil J. Ghelani,
  • Neha S. Kwatra and
  • Christopher F. Spurney

26 March 2013

Background: Coronary artery involvement is seen in approximately 15–20% of children with Kawasaki disease. There is conflicting literature regarding the clinical and laboratory findings associated with coronary artery involvement. In this retrospecti...

  • Review
  • Open Access
9 Citations
8,984 Views
12 Pages

25 March 2013

Parkinson’s disease is the second most prevalent disease of the brain. It is characterized by midbrain dopaminergic neuronal degeneration accompanied by Lewy bodies, intra-cytoplasmic neuronal inclusions that consist mainly of alpha-synuclein. The ca...

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Diagnostics - ISSN 2075-4418