Osteoporosis Is Associated with an Increased Risk of Colorectal Neoplasms Regardless of Sex: Nationwide Population-Based Cohort Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Study Variables
2.3. Statistical Analyses
3. Results
3.1. Baseline Characteristics
3.2. Risks for Colonic Neoplasms in Osteoporosis; Analyses by Histologic Subclasses
3.3. Subgroup Analyses by Baseline Characteristics
3.4. Sensitivity Analysis
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Variables | Total, n (%) | Osteoporosis, n (%) | p Value | |
---|---|---|---|---|
n = 68,610 | No (n = 8224) | Yes (n = 60,386) | ||
Colorectal neoplasms | <0.0001 | |||
No | 60,904 (88.8) | 7556 (91.9) | 53,348 (88.3) | |
Yes | 7706 (11.2) | 668 (8.1) | 7038 (11.7) | |
Low-grade adenoma | <0.0001 | |||
No | 62,263 (90.7) | 7644 (92.9) | 54,519 (90.4) | |
Yes | 6347 (9.3) | 580 (7.1) | 5767 (9.6) | |
High-grade adenoma/CIS | 0.6563 | |||
No | 68,458 (99.8) | 8204 (99.8) | 60,254 (99.8) | |
Yes | 152 (0.2) | 20 (0.2) | 132 (0.2) | |
Non-invasive CRN * | <0.0001 | |||
No | 62,139 (90.6) | 7630 (92.8) | 54,509 (90.3) | |
Yes | 6471 (9.4) | 594 (7.2) | 5877 (9.7) | |
Invasive CRC | <0.0001 | |||
No | 66,908 (97.5) | 8109 (98.6) | 58,799 (97.4) | |
Yes | 1702 (2.5) | 115 (1.4) | 1587 (2.6) | |
Sex | <0.0001 | |||
Male | 10,076 (14.7) | 3931 (47.8) | 6145 (10.2) | |
Female | 58,534 (85.3) | 4293 (52.2) | 54,241 (89.8) | |
Age, years | <0.0001 | |||
50–54 | 8854 (12.9) | 2251 (27.4) | 6603 (10.9) | |
55–59 | 10,504 (15.3) | 1576 (19.2) | 8928 (14.8) | |
60–64 | 11,691 (17.0) | 1155 (14.0) | 10,536 (17.5) | |
65–69 | 14,317 (20.9) | 1016 (12.4) | 13,301 (22.0) | |
70–74 | 11,028 (16.1) | 987 (12.0) | 10,041 (16.6) | |
75–79 | 6863 (10.0) | 660 (8.0) | 6203 (10.3) | |
≥80 | 5353 (7.8) | 579 (7.0) | 4774 (7.9) | |
CCI | <0.0001 | |||
0 | 16,663 (24.3) | 1839 (22.4) | 14,824 (24.6) | |
1 | 17,694 (25.8) | 1795 (21.8) | 15,899 (26.3) | |
2 | 13,936 (20.3) | 1588 (19.3) | 12,348 (20.4) | |
3 or more | 20,317 (29.6) | 3002 (36.5) | 17,315 (28.7) | |
Income level | 0.7050 | |||
0–3 | 16,196 (23.6) | 1961 (23.8) | 14,235 (23.6) | |
4–7 | 22,909 (33.4) | 2714 (33.0) | 20,195 (33.4) | |
8–10 | 29,505 (43.0) | 3549 (43.2) | 25,956 (43.0) |
Variables | Osteoporosis, n (%) | Crude OR (95% CI) | p Value | Adjusted OR (95% CI) | p Value | |
---|---|---|---|---|---|---|
No | Yes | |||||
Colorectal neoplasms | 668 | 7038 | 1.49 (1.37–1.62) | <0.0001 | 1.91 (1.75–2.09) | <0.0001 |
Low-grade adenoma | 580 | 5767 | 1.39 (1.27–1.52) | <0.0001 | 1.89 (1.72–2.09) | <0.0001 |
High-grade adenoma/CIS | 20 | 132 | 0.90 (0.56–1.44) | 0.6564 | 1.30 (0.77–2.19) | 0.3190 |
Non-invasive CRN * | 594 | 5877 | 1.38 (1.27–1.51) | <0.0001 | 1.88 (1.71–2.07) | <0.0001 |
Invasive CRC | 115 | 1587 | 1.90 (1.57–2.30) | <0.0001 | 1.83 (1.49–2.24) | <0.0001 |
Variables | Adjusted OR | 95% CI | p Value |
---|---|---|---|
Sex | |||
Male | 1.66 | 1.45–1.91 | <0.0001 |
Female | 2.06 | 1.83–2.32 | <0.0001 |
Age | |||
50–54 | 1.95 | 1.66–2.30 | <0.0001 |
55–59 | 1.85 | 1.53–2.24 | <0.0001 |
60–64 | 2.07 | 1.64–2.60 | <0.0001 |
65–69 | 1.59 | 1.25–2.02 | 0.0001 |
70–74 | 2.28 | 1.69–3.07 | <0.0001 |
75–79 | 1.62 | 1.10–2.40 | 0.0148 |
≥80 | 1.30 | 0.78–2.16 | 0.3202 |
CCI | |||
0 | 1.80 | 1.48–2.20 | <0.0001 |
1 | 1.88 | 1.55–2.27 | <0.0001 |
2 | 1.79 | 1.48–2.17 | <0.0001 |
3 or more | 2.04 | 1.76–2.38 | <0.0001 |
Income level | |||
0–3 | 1.69 | 1.40–2.02 | <0.0001 |
4–7 | 1.71 | 1.46–1.99 | <0.0001 |
8–10 | 2.23 | 1.94–2.57 | <0.0001 |
Variables | Osteoporosis | Crude OR (95% CI) | p Value | Adjusted OR (95% CI) | p Value | |
---|---|---|---|---|---|---|
No | Yes | |||||
Colonic neoplasms | 419 | 3679 | 1.37 (1.23–1.53) | <0.0001 | 1.75 (1.56–1.97) | <0.0001 |
Low-grade adenoma | 378 | 3161 | 1.29 (1.16–1.45) | <0.0001 | 1.74 (1.54–1.96) | <0.0001 |
High-grade adenoma/CIS | 14 | 70 | 0.75 (0.42–1.34) | 0.3375 | 1.26 (0.65–2.41) | 0.4931 |
Non-invasive CRN * | 387 | 3211 | 1.28 (1.15–1.43) | <0.0001 | 1.73 (1.53–1.95) | <0.0001 |
Invasive CRC | 54 | 672 | 1.90 (1.44–2.51) | <0.0001 | 1.78 (1.32–2.39) | <0.0001 |
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Yoo, S.H.; Nam, J.H.; Oh, D.J.; Park, G.U.; Kim, S.H.; Kang, H.W.; Kim, J.H.; Lim, Y.J. Osteoporosis Is Associated with an Increased Risk of Colorectal Neoplasms Regardless of Sex: Nationwide Population-Based Cohort Study. Diagnostics 2024, 14, 666. https://doi.org/10.3390/diagnostics14060666
Yoo SH, Nam JH, Oh DJ, Park GU, Kim SH, Kang HW, Kim JH, Lim YJ. Osteoporosis Is Associated with an Increased Risk of Colorectal Neoplasms Regardless of Sex: Nationwide Population-Based Cohort Study. Diagnostics. 2024; 14(6):666. https://doi.org/10.3390/diagnostics14060666
Chicago/Turabian StyleYoo, Seung Heon, Ji Hyung Nam, Dong Jun Oh, Geun U Park, Sang Hoon Kim, Hyoun Woo Kang, Jae Hak Kim, and Yun Jeong Lim. 2024. "Osteoporosis Is Associated with an Increased Risk of Colorectal Neoplasms Regardless of Sex: Nationwide Population-Based Cohort Study" Diagnostics 14, no. 6: 666. https://doi.org/10.3390/diagnostics14060666