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Volume 12
Issue 4
10.3390/diagnostics12040781
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Article

Assessing the Role of Lipopolysaccharide (LPS) Receptor (CD14) in Septic Cardiomyopathy: The Value of Immunohistochemical Diagnostics

by
Peter Michael Reil
1,
Teodor Traian Maghiar
2,
Narcis Vîlceanu
2,
Andrei Pascalau
2,*,
Claudia Teodora Judea Pusta
2,
Florin Marcu
3,
Simona Cavalu
4 and
Ovidiu Pop
2
1
Klinikum Ingolstadt GmbH, 85049 Ingolstad, Germany
2
Department of Morphology Sciences, University of Oradea, 410087 Oradea, Romania
3
Department of Psycho-Neuro-Sciences and Recovery, University of Oradea, 410087 Oradea, Romania
4
Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania
*
Author to whom correspondence should be addressed.
Diagnostics 2022, 12(4), 781; https://doi.org/10.3390/diagnostics12040781
Submission received: 14 January 2022 / Revised: 28 February 2022 / Accepted: 16 March 2022 / Published: 23 March 2022
(This article belongs to the Section Pathology and Molecular Diagnostics)
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Abstract

Sepsis-induced myocardial dysfunction (SIMD) is one of the major predictors of morbidity and mortality of sepsis. A high percentage of patients with SIMD develop a status similar to cardiogenic shock. A high level of bacterial lipopolysaccharide (LPS) associated with an overexpression of CD14 acts as the trigger for the release of a broad spectrum of cytokines. Our study aimed to understand the correlation between septic cardiomyopathy and CD14 immunohistochemical expression. The study included 29 patients who died of septic shock. Increased values of membranous CD14 and soluble CD14 in the heart tissue were correlated with adverse patient evolution. A high cellular expression of CD14 was noted in the study group vs. the control group (p = 0.0013). Therefore, a close positive association between the amount of LPS related to sCD14 and the cellular expression of mCD14 is probable. By extrapolation, we suggest that a large amount of sCD14 detected in the cardiac tissue will activate the mCD14–TRL4–LBP–LPS complex, which in turn will induce an inadequate immune response, resulting in heart damage proportional to the amount of LPS. CD14 could represent a valuable marker for septic cardiomyopathy; thus, apoptosis of cardiomyocytes could be foreseen by its high value.
Keywords: septic cardiomyopathy; apoptosis; CD14; lipopolysaccharide; cytokines septic cardiomyopathy; apoptosis; CD14; lipopolysaccharide; cytokines

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MDPI and ACS Style

Reil, P.M.; Maghiar, T.T.; Vîlceanu, N.; Pascalau, A.; Judea Pusta, C.T.; Marcu, F.; Cavalu, S.; Pop, O. Assessing the Role of Lipopolysaccharide (LPS) Receptor (CD14) in Septic Cardiomyopathy: The Value of Immunohistochemical Diagnostics. Diagnostics 2022, 12, 781. https://doi.org/10.3390/diagnostics12040781

AMA Style

Reil PM, Maghiar TT, Vîlceanu N, Pascalau A, Judea Pusta CT, Marcu F, Cavalu S, Pop O. Assessing the Role of Lipopolysaccharide (LPS) Receptor (CD14) in Septic Cardiomyopathy: The Value of Immunohistochemical Diagnostics. Diagnostics. 2022; 12(4):781. https://doi.org/10.3390/diagnostics12040781

Chicago/Turabian Style

Reil, Peter Michael, Teodor Traian Maghiar, Narcis Vîlceanu, Andrei Pascalau, Claudia Teodora Judea Pusta, Florin Marcu, Simona Cavalu, and Ovidiu Pop. 2022. "Assessing the Role of Lipopolysaccharide (LPS) Receptor (CD14) in Septic Cardiomyopathy: The Value of Immunohistochemical Diagnostics" Diagnostics 12, no. 4: 781. https://doi.org/10.3390/diagnostics12040781

APA Style

Reil, P. M., Maghiar, T. T., Vîlceanu, N., Pascalau, A., Judea Pusta, C. T., Marcu, F., Cavalu, S., & Pop, O. (2022). Assessing the Role of Lipopolysaccharide (LPS) Receptor (CD14) in Septic Cardiomyopathy: The Value of Immunohistochemical Diagnostics. Diagnostics, 12(4), 781. https://doi.org/10.3390/diagnostics12040781

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