Diagnostic Value of Endoscopic Ultrasound after Neoadjuvant Chemotherapy for Gastric Cancer Restaging: A Meta-Analysis of Diagnostic Test
Abstract
:1. Introduction
2. Materials and Methods
2.1. Literature Search Strategy
2.2. Selection Criteria
2.3. Quality Assessment
2.4. Data Extraction
2.5. Statistical Analysis
3. Results
3.1. Electronic Search Results and Study Characteristics
3.2. Quality Assessment of the Included Studies
3.3. Data Synthesis
3.3.1. T1 Restage
3.3.2. T2 Restage
3.3.3. T3 Restaging
3.3.4. T4 Restaging
3.3.5. T1+T2 Restaging
3.3.6. N Restage (N0 vs. N1+)
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Study | Country | No of Patients (Included/Total) | Age Mean, Range | Gender Male/Female | Location | AICC/UICC TNM Edition |
---|---|---|---|---|---|---|
Ajani 1999 [19] | United States of America (Texas) | 13/30 | 56, 33–75 | 19/11 | Proximal 21 Distal 9 | 5th ed. |
Bohle 2017 [20] | Germany | 67 | 61, 29–80 | 48/19 | Gastric 18 Esophago-gastric junction 44 Distal esophagus 5 | 7th ed. |
Guo 2014 [21] | China | 48 | 62, 34–80 | 33/15 | Cardia 9 Distal+proximal 39 | NA |
Kelsen 1996 [22] | United States of America (New York) | 37/60 | 57, 26–75 | 40/20 | Proximal 31 Distal 28 Linistis Plastica 1 | NA |
Park 2008 [23] | Republic of Korea | 40/44 | 58, 36–70 | 30/10 | Proximal 6 Distal 27 Whole stomach 7 | 6th ed. |
Redondo-Cerezo 2017 [15] | Spain | 80/256 | 67.6 (SD = 12.1) | 178/78 | Fundus 26 Body 102 Antrum 100 Lesser curvature/incisura angularis 30 | 7th ed. |
Stage | Pooled Sensitivity (95%, CI) | Pooled Specificity (95%, CI) | Pooled DOR (95%, CI) | AUC Partial AUC (Restricted to Observed FPRs and Normalized) |
---|---|---|---|---|
T2 | 29% (11–57%) | 89% (83–94%) | 3.96 (0.95–16.62) | 0.85 (0.25) |
T3 | 71% (45–89%) | 49% (31–68%) | 2.28 (1.08–3.46) | 0.62 (0.69) |
T4 | 56% (37–72%) | 87% (67–95%) | 4.79 (0.43–6.33) | 0.71 (0.58) |
T1+T2 | 45% (7–89%) | 86% (72–94%) | 4.8 (2.02–6.93) | 0.84 (0.65) |
N | 53% (44–62%) | 72% (53–85%) | 2.97 (1.19–7.44) | 0.55 (0.52) |
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Sacerdotianu, V.M.; Ungureanu, B.S.; Iordache, S.; Turcu-Stiolica, A.; Facciorusso, A.; Crinò, S.F.; Saftoiu, A. Diagnostic Value of Endoscopic Ultrasound after Neoadjuvant Chemotherapy for Gastric Cancer Restaging: A Meta-Analysis of Diagnostic Test. Diagnostics 2022, 12, 100. https://doi.org/10.3390/diagnostics12010100
Sacerdotianu VM, Ungureanu BS, Iordache S, Turcu-Stiolica A, Facciorusso A, Crinò SF, Saftoiu A. Diagnostic Value of Endoscopic Ultrasound after Neoadjuvant Chemotherapy for Gastric Cancer Restaging: A Meta-Analysis of Diagnostic Test. Diagnostics. 2022; 12(1):100. https://doi.org/10.3390/diagnostics12010100
Chicago/Turabian StyleSacerdotianu, Victor Mihai, Bogdan Silviu Ungureanu, Sevastita Iordache, Adina Turcu-Stiolica, Antonio Facciorusso, Stefano Francesco Crinò, and Adrian Saftoiu. 2022. "Diagnostic Value of Endoscopic Ultrasound after Neoadjuvant Chemotherapy for Gastric Cancer Restaging: A Meta-Analysis of Diagnostic Test" Diagnostics 12, no. 1: 100. https://doi.org/10.3390/diagnostics12010100